Efficacy of Pelvic Diffusion Weighted MRI Prior to Prostate Biopsy in Patients with elevated tPSA Level for Determination of Malignant Lesions
Zidan, A., Mahmoud, A., Said, A., Abdulallah, R. (2023). Efficacy of Pelvic Diffusion Weighted MRI Prior to Prostate Biopsy in Patients with elevated tPSA Level for Determination of Malignant Lesions. EKB Journal Management System, 4(2), 76-91. doi: 10.21608/ejmr.2022.112787.1175
Ahmed Abdel Fattah Zidan; Amany Rady Mahmoud; Ahmed Hesham Said; Rabee Mohammed Abdulallah. "Efficacy of Pelvic Diffusion Weighted MRI Prior to Prostate Biopsy in Patients with elevated tPSA Level for Determination of Malignant Lesions". EKB Journal Management System, 4, 2, 2023, 76-91. doi: 10.21608/ejmr.2022.112787.1175
Zidan, A., Mahmoud, A., Said, A., Abdulallah, R. (2023). 'Efficacy of Pelvic Diffusion Weighted MRI Prior to Prostate Biopsy in Patients with elevated tPSA Level for Determination of Malignant Lesions', EKB Journal Management System, 4(2), pp. 76-91. doi: 10.21608/ejmr.2022.112787.1175
Zidan, A., Mahmoud, A., Said, A., Abdulallah, R. Efficacy of Pelvic Diffusion Weighted MRI Prior to Prostate Biopsy in Patients with elevated tPSA Level for Determination of Malignant Lesions. EKB Journal Management System, 2023; 4(2): 76-91. doi: 10.21608/ejmr.2022.112787.1175

Efficacy of Pelvic Diffusion Weighted MRI Prior to Prostate Biopsy in Patients with elevated tPSA Level for Determination of Malignant Lesions

Egyptian Journal of Medical Research
Volume 4, Issue 2, April 2023, Page 76-91  XML PDF (674.55 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.112787.1175
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Authors
Ahmed Abdel Fattah Zidan1; Amany Rady Mahmoud email 2; Ahmed Hesham Saidorcid 1; Rabee Mohammed Abdulallah3
1Radiology department, Faculty of medicine, Beni_Suef University, Egypt.
2Radiology department, Elwasta central hospital, MOPH.
3Urology department, Faculty of medicine, Beni_Suef University, Egypt.
Abstract
Aim: the aim of this research to examine the influence of TRUS-guided biopsy samples from specified lesions in diffusion-weighted MRI on the detection rate of prostate cancer (MRI). Patients and Methods: This study cross sectional analytical study with follow up the results of biopsy was conducted on 25 patients with elevated PSA from 2.5 to 20 ng/ml undergone diffusion weighted MRI before TRUS guided biopsy. Patients were referred to the diagnostic radiology department from the outpatient clinic of urology department at Beni-Suef University Hospital from September 2018 to December 2020.The study explained to all participants and written informed consent taken from them before starting the  study and the approval of ethical committee of Beni-Suef was taken. Results: There were 72% of the studied patients had benign prostatic lesions and 28% had malignant lesions. There was a statistically significant higher level of PSA among patients with restricted MRI diffusion than who had normal MRI diffusion (P-value=0.030). The sensitivity of MRI diffusion in detection of malignant prostate masses was 71.4% its specificity was 94.4% %, the PPV was 83.3% and the NPV was 89.5%. Conclusion: In conclusion, transrectal ultrasonography (TRUS) guided biopsy samples from pre-determined lesions in diffusion-weighted MRI (MRI) resulted in an increase in the detection rate of prostate cancer while lowering the excessive biopsy rate.
Keywords
DWI; MRI; Prostate; tPSA
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