Indomethacin Prior to Difficult Embryo Transfer is it a Solution? | ||
| Evidence Based Women's Health Journal | ||
| Article 3, Volume 13, Issue 2, May 2023, Pages 134-139 PDF (319.83 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2022.150089.1189 | ||
| Authors | ||
| Amira Saied* 1; Mona Shabaan2; Yasmin Bassiouny1; Ayman Hassan3; Radwa Fahmy4 | ||
| 1Obstetrics and gynecology Faculty of medicine Cairo University Cairo Egypt | ||
| 2Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt | ||
| 3Obstetrics and gynecology , Kasr Al Aini , Cairo , Egypt | ||
| 4Obstetrics and Gynecology department, faculty of medicine, Cairo University | ||
| Abstract | ||
| Objectives: To find out the role of administration of indomethacin prior to embryo transfer in cases of difficult mock embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycle in improving the reproductive outcomes. Study Design: It is a randomized controlled trial. Patients and Methods: The study was conducted in the in vitro fertilization units of the University hospital as well as a private unit from the 2nd of June 2018 till the 2nd of December 2018. A total of two hundred in vitro fertilization/ intra cytoplasmic sperm injection cycles who had difficult mock embryo transfer on the day of ovum pick up. Women were randomly assigned into two groups; group A (study group: n=100) will receive 100mg indomethacin rectal suppository 1-2 hours before embryo transfer, while group B (control group: n=100) did not receive any medications before the embryo transfer. Results: Both groups were comparable regarding age, body mass index, basal hormones, and cause of infertility. The implantation (23.7% vs 20.8%, P value 0.906), clinical pregnancy (48% vs 40%, P value 0.254), and ongoing pregnancy (40% vs 36%, P value 0.560) rates were higher in the indomethacin group, but not reaching statistical significance. Conclusion: Indomethacin, as adjuvant therapy, has no statistically significant role on in cases with difficult embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycles. | ||
| Keywords | ||
| Difficult embryo transfer; implantation rate; indomethacin; IVF/ICSI cycles; pregnancy rate | ||
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