Design Synthesis and Characterization of Novel Quinazolin-4(3H)-one Derivatives with Anticipated Pharmacological Efficacy | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 6, June 2023, Pages 493-498 PDF (463.99 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.207385.7905 | ||
| Authors | ||
| Mohamed Elbadry1; Ahmed Kamel El-Ziaty* 2 | ||
| 1Ain Shams University | ||
| 2Ain shams University | ||
| Abstract | ||
| The previously described 6,8-dibromo-2-(3,4-dichlorophenyl)quinazolin-4(3H)-one 1 was created and employed as a building block for the synthesis of quinazolinone derivatives 2–11 with considerable predicted medicinal activity. The reaction of the hydrazinyl derivative 9 with carbon disulfide led to the 7,9-dibromo-5-(3,4-dichlorophenyl)-[1,2,4]triazolo[4,3-c]quinazoline-3(2H)-thione 12. From the compound 6,8-dibromo-2-(3,4-dichlorophenyl)quinazoline-4(3H)-thione 8 came the quinazolinone derivatives 13–16. Physical and chemical methods were used to characterize constructed products. | ||
| Keywords | ||
| quinazolin-4(3H)-one; quinazoline-4(3H)-thione and triazolo[4; 3-c]quinazoline | ||
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