Assessment of Serum Proinflammatory Cytokines and Some Associated Haematobiochemical Indices in An experimental Canine Trypanosomiasis | ||
| Egyptian Journal of Veterinary Sciences | ||
| Volume 54, Issue 5, September and October 2023, Pages 815-823 PDF (1.3 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2023.199184.1460 | ||
| Authors | ||
| Simon Abah Victor Abakpa* 1; Temiloluwa J. Fambegbe2; Eniope B. Oluwayinka3; Adeniyi O. Egbetade3; Samson A. Raman4; Kemi R. Idowu5; Edwin F. Okpe3 | ||
| 1Department of Veterinary Medicine, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria. | ||
| 2Department of Veterinary Medicine, , Nigeria | ||
| 3Department of Veterinary Medicine, Nigeria | ||
| 4Department of Veterinary Physiology and Biochemistry, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Nigeria | ||
| 5Veterinary Teaching hospital, Federal University of Agriculture, Abeokuta, Nigeria | ||
| Abstract | ||
| THIS research assessed the concentrations of tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukin-6 (IL-6) in Nigerian indigenous dogs (NID) experimentally infected with Trypanosoma congolense (T. congolense) and correlated with some haematological and biochemical indices. Fifteen NID of weight (9.3±1.04 kg) were randomly assigned into three groups of five each. Group A was uninfected and untreated. Group B received T. congolense (2.5 x 105), but untreated. Group C received T. congolense (2.5 x 105) and treated with diminazene aceturate on day 17 post-infection (pi). Blood was obtained pre-infection, pi and post-treatment (pt) for cytokines assessment using ELISA. Serum TNF-α increased significantly (p < 0.05) in groups B and C on days 10 and 17 pi but decreased on day 5 pt in group C compared to groups A and B. Serum IL-6 increased significantly in groups B and C on days 1 to 22 pi. Both TNF-α and IL-6 correlated positively with monocytes count, creatinine, and urea. Serum TNF-α correlated negatively with PCV, erythrocytes count, haemoglobin concentration (Hb) and albumin, while IL-6 correlated negatively with on PCV, Hb and albumin. In conclusion, IL-6 was elevated post infection and remained elevated post treatment. Tumour necrosis factor - alpha concentration was elevated in NID infected with T. congolense, but decreased significantly post treatment. Both IL-6 and TNF-α positively or negatively associated with assessed haematological and biochemical indices. In conclusion, proinflammatory cytokines are elevated in NID experimentally infected with T. congolense and caused some pathology. | ||
| Keywords | ||
| Proinflammatory cytokines; diminazene aceturate; dogs; T. congolense | ||
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