GC/MS Profiling of Becium grandiflorum Essential Oil and Evaluation of Its Antiviral Activity | ||||
| Archives of Pharmaceutical Sciences Ain Shams University | ||||
| Volume 7, Issue 1, June 2023, Page 87-96 PDF (582.47 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aps.2023.202342.1114 | ||||
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| Authors | ||||
Christine Fahim1; Nehal Ibrahim   2; Noha Swilam1; Rola M. Milad2
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| 1Department of Pharmacognosy, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City 11837, Egypt. | ||||
| 2Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt. | ||||
| Abstract | ||||
| Genus Becium of Lamiaceae family encounters numerous medicinally and economically valued aromatic plants. The hydrodistilled essential oil of Becium grandiflorum (Lam.) Pic.Serm. aerial part was analyzed using GC/MS. A total of 32 compounds amounting to 99.68% of the essential oil were identified. Oxygenated diterpenes constituted the largest share (43.45%) in the studied oil followed by sesquiterpenes hydrocarbons (34.24%). Pimara-7,15-dien-3-ol (20.58%), 3-α-hydroxymanool (14.07%), caryophyllene (8.17%), sandaracopimaradiene (7.98%), selina-3,7(11)-diene (5.61%), and germacrene D (4.95%) are the chief identified compounds in B. grandiflorum essential oil. The essential oil was assessed for its antiviral potential against herpes simplex virus 1 (HSV-1) at a non-cytotoxic concentration using cytopathic effect (CPE) inhibition assay on the Vero cell line. B. grandiflorum essential oil exhibited a pronounced in vitro cytotoxicity against Vero cells with 50 % cytotoxic concentration (CC50) of 7.75 ± 0.84 µg/mL and weak anti-HSV-1 potency with percent inhibition of 21.36 ± 2.13 at a maximum non-toxic concentration of 1 µg/mL. | ||||
| Keywords | ||||
| Becium grandiflorum; essential oil; GC/MS; antiviral; MTT assay | ||||
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