Spirulina platensis protects against L-methionine induced hyperhomocysteinemia by abrogation of oxidative stress markers, hyperhomocysteine and inflammation in rats
Hussein, S., Ahmed, T., Ali, A. (2017). Spirulina platensis protects against L-methionine induced hyperhomocysteinemia by abrogation of oxidative stress markers, hyperhomocysteine and inflammation in rats. EKB Journal Management System, 33(2), 257-270. doi: 10.21608/bvmj.2017.30483
Samy Ali Hussein; Tahia E. Ahmed; Aliaa H. Ali. "Spirulina platensis protects against L-methionine induced hyperhomocysteinemia by abrogation of oxidative stress markers, hyperhomocysteine and inflammation in rats". EKB Journal Management System, 33, 2, 2017, 257-270. doi: 10.21608/bvmj.2017.30483
Hussein, S., Ahmed, T., Ali, A. (2017). 'Spirulina platensis protects against L-methionine induced hyperhomocysteinemia by abrogation of oxidative stress markers, hyperhomocysteine and inflammation in rats', EKB Journal Management System, 33(2), pp. 257-270. doi: 10.21608/bvmj.2017.30483
Hussein, S., Ahmed, T., Ali, A. Spirulina platensis protects against L-methionine induced hyperhomocysteinemia by abrogation of oxidative stress markers, hyperhomocysteine and inflammation in rats. EKB Journal Management System, 2017; 33(2): 257-270. doi: 10.21608/bvmj.2017.30483

Spirulina platensis protects against L-methionine induced hyperhomocysteinemia by abrogation of oxidative stress markers, hyperhomocysteine and inflammation in rats

Benha Veterinary Medical Journal
Article 28, Volume 33, Issue 2, December 2017, Pages 257-270    PDF (421.1 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2017.30483
Authors
Samy Ali Hussein1; Tahia E. Ahmed2; Aliaa H. Ali3
1Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt.
2Department of Nutrition and clinical nutrition, Faculty of Vet. Med., Benha University, Egypt
3Department of Biochemistry, Faculty of Vet. Med., Benha University, Egypt
Abstract
Spirulina platensis have therapeutic functions such as antioxidant, anti-bacterial, antiviral, anticancer, anti-inflammatory, anti-allergic and anti-diabetic. The purpose of this study was to evaluate the protective effect of spirulina platensis on L-methionine induced hyperhomocysteinemia (HHcy) in rats. Thirty male albino rats were divided into three equal groups. Group I (control normal): rats administered distilled water. Group II (hyperhomocysteinemic group (HHcy): rats received L-methionine (1.7 gm/kg body weight/day) orally for continuous 8 weeks. Group III (HHcy + spirulina platensis): rats received spirulina (1.5 gm/kg body weight/day) orally for 4 weeks after induction of hyperhomocysteinemia. The obtained results showed significant increase in serum homocysteine, lipids profile (total cholesterol and triacylglycerols), liver marker enzymes (ALT, AST and ALP), liver L-MDA and pro-inflammatory cytokines (TNF-α and IL-8) gene expression level in hyperhomocysteinemic (HHcy) rats. However, liver SOD activity and GSH concentration were markedly decreased. Spirulina treatment to L-methionine induced HHcy in rats caused significant improvement of all previous parameters towards its normal ranges. These results suggested that, spirulina treatment exerts a protective effect on HHcy by reduction of oxidative stress marker, inflammation and hyperhomocysteinemia in rats through free radical scavenging and anti-inflammatory activities as well as regenerating endogenous antioxidant defense system mechanisms.
Keywords
L-methionine; Hyperhomocysteinemia; Spirulina; Oxidative Stress
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