Ganglion Cell Complex and Optical Coherence Tomography Angiography in Assessment of Early Diabetic Retinal Changes | ||||
| Suez Canal University Medical Journal | ||||
| Article 4, Volume 26, Issue 3, March 2023, Page 24-35 PDF (627.9 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2023.305076 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed Mohamed Abd El- Basset Mourad  ; Hussein Salah El-Deen EL-Nahass; Mahmoud Ahmed Ali Ghonaim
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| Ophthalmology Department, Faculty of Medicine, Suez Canal University. Ismailia, Egypt. | ||||
| Abstract | ||||
| Background: Diabetes mellitus is a chronic disorder of glucose metabolism that has serious clinical consequences including microvascular (retinopathy, nephropathy, neuropathy) and macrovascular (ischemic heart disease, stroke, peripheral vascular disease) complications. Diabetic retinopathy (DR) is a major cause of visual impairment worldwide in working-age individuals and is a micro-vascular complication. Aim and objectives: The aim of this study is to recognize the contributions of microvascular and neural changes in the pathogenesis of diabetic retinopathy. Patients and methods:We conduct a cross-sectional analytical study of 22 eyes of diabetic patients and 22 eyes of matched controls, evaluated for retinal neuro-degeneration and micro-vascular changes at the Ophthalmology outpatient clinic, Suez Canal University (SCU) Hospital, Ismailia using OCT and OCTA. Results: Micro-vascular changes in the diabetic group showed mean±SD of the s-FAZ was 452.80±193.0µm2,mean±SD d-FAZ was 717.71±233.13 µm2 and mean±SD of the foveal vessel density was 15.93±6.28%and in the control group showed mean±SD of s-FAZ was 285.40±68.65µm2, mean±SD of d-FAZ was 481.70±101.17µm2 and mean±SD of foveal vessel density was 20.33±3.10% and neurodegenerative changes showed mean±SD of macular GCL+ layer thickness for the diabetic group was 61.41±5.20µm while for the control group was 66.82±6.82µm and mean±SD of macular GCL++ layer thickness for the diabetic group was 98.73±7.64µm and for the control group was 106.41±11.59µm. Conclusion: Micro-vascular assessment in diabetic patients showed there is enlargement in s-FAZ and d-FAZ areas and their neural assessment showed there is thinning in the inner retinal layers, so there is a negative relationship between them. | ||||
| Keywords | ||||
| diapetic retinopathy; microvascular; retinal neuro-degeneration | ||||
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