Ocular Comorbidities in Juvenile Idiopathic Arthritis | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 258, Volume 91, Issue 1, April 2023, Page 5421-5427 PDF (608.82 K) | ||||
| DOI: 10.21608/ejhm.2023.305755 | ||||
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| Authors | ||||
| Mayada Khalil* ; Ali Ibrahim Fouda; Abd El Wahab Shams Eldin Elbrashy; Ahmed Tabal; Lamyaa Mohammed Hashem | ||||
| Abstract | ||||
| Background: Uveitis is the most widespread and serious extra-articular sign of juvenile idiopathic arthritis (JIA), which is the most prevalent rheumatic condition in children. Despite more effective treatment options, the prevalence of JIA illness remains high, making it so difficult to assess the disease's outcomes—especially if extra-articular symptoms are present. The maintenance of sight and effective care depend on early detection. Objective: The aim of the current study was to scan the eyes of kids with JIA in order to find any ocular symptoms as soon as possible and stop any problems that could result in blindness and vision loss. Patients and methods: The study included 97 children who have JIA of both sexes, their age was under 16. All patients were underwent to a clinical examination (general, musculoskeletal, and ophthalmic examination), as well as laboratory testing (ESR, RF, ANA, HLA-B27, and CRP). Results: Ocular complications of JIA were significant (P<0.05) in uveitis group compared with group without uveitis regarding synechia, macular edema, keratopathy, glaucoma, and mild visual impairment. Correlation showed that disease severity (JDAS 27) is independent risk factors affecting uveitis (r=0.7353, P=0.001). Other risk factors like disease duration, age, JIA subtype and anterior chamber cells as well as CRP and ESR, TLC, and ANA positivity were significantly correlated with uveitis (r=0.976 P=0.032, r=0.728 P=0.014, r=0.932 P=0.042, r=0.963 P=0.026, r=0.854 P=0.045, r=0.768 P=0.036, r=0.697 P=0.057, r=0.719 P=0.019, consecutively). Conclusion: JIA-related uveitis might have disastrous consequences. Today, clinical and demographic criteria have been used largely to estimate the risk of developing uveitis in JIA patients. To uncover patient-specific risk variables, recent studies employed molecular proteomic and cellular phenotyping techniques. | ||||
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