Can Upregulation of CXCR3 By Phototherapy Improve Vitiligo? It’s Role in Chronicity | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 19, Volume 92, Issue 1, July 2023, Pages 5595-5603 PDF (582.04 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2023.306171 | ||
| Authors | ||
| Fatma Al-Zahraa; Nesma Hussein AbdelHay* ; Seham Adel; Heba Mahmoud Diab; Amal Mansour | ||
| Faculty of Medicine, Ain Shams University | ||
| Abstract | ||
| Background: Vitiligo is melanocyte death that is affected by oxidative stress which elevated levels of reactive oxygen species can elicit an immune response, and ultimately cause melanocytic death. Objective: The current study aimed to investigate the impact of Narrowband Ultraviolet B (NBUVB) and excimer laser phototherapy on C-X-C motif chemokine receptor 3B expression in vitiligo patients and its impact on vitiligo improvement. Patients and methods: CXCR3B mRNA expression was measured in skin of25 patients suffering from non-segmental vitiligo before and after generalized ‘NBUVB’ and targeted phototherapy ‘Excimer laser’. All biopsies were kept in - 80C till RNA extraction that was performed utilizing QIAGEN RNeasy Little Pack, QuantiTect Switch Record Unit and QuantiNova SYBR Green PCR Unit. Results: After phototherapy patients with vitiligo had higher CXCR3B mRNA levels, in addition, this was higher in excimer bunch treatment than NBUVB. Conclusion: Such findings draw attention to CXCR3B as an inherited abnormality in vitiligo patients' skin and raise concerns about its potential contributions in maintaining vitiligo or triggering relapses & chronicity. | ||
| Keywords | ||
| Vitiligo; CXCR3; phototherapy; mRNA; PCR; Intervention study; Ain Shams University | ||
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