Short-Term Systo-Diastolic Myocardial Recovery Following Primary Versus Pharmaco-Invasive Percutaneous Coronary Intervention Of Acute Anterior ST Elevation Myocardial Infarction | ||
| Zagazig University Medical Journal | ||
| Article 17, Volume 29, Issue 5, September and October 2023, Pages 1355-1364 PDF (403.14 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2023.218308.2812 | ||
| Authors | ||
| Mohamed Amin1; Mohammad Mahmoud Elshwadfy2; Ahmed Shafie Ammar3; Ahmed El Zayat4; Islam Ghanem* 5 | ||
| 1Zagazig university. Faculty of medicine, cardiology department | ||
| 2Cardiology, Zagazig university | ||
| 3Professor, Cardiology, Zagazig | ||
| 4Cardiology | ||
| 5Lecturer of Cardiology, Faculty of medicine, Zagazig university | ||
| Abstract | ||
| Background: The preferred reperfusion strategy for ST-elevation myocardial infarction (STEMI) is primary percutaneous coronary intervention (PPCI). Another mode is transfer for immediate angioplasty following thrombolytic therapy (Pharmaco-invasive PCI). Objective: to assess the short-term recovery of left ventricular systolic and diastolic functions following primary versus pharmaco-invasive PCI Subjects and methods: We enrolled one hundred patients admitted to Zagazig university hospital, Egypt with anterior STEMI . first group underwent primary PCI and the second group underwent pharmaco-invasive PCI w. Both groups were followed-up for three months to assess systolic and diastolic myocardial recovery. Systolic function was assessed by EF and GLS. Diastolic function as assessed by E/e` ratio. A unique Doppler index addressing both systolic and diastolic functions [E/(e'×s')] index assessed. Results: After revascularization there was a modest improvement in all parameters without significant difference regarding ejection fraction, but there was a statistically significant difference between the two groups regarding GLS, E/e` ratio and E/(e`x s`) ratio with a P value of 0.02, 0.003 and 0.004 respectively. Three months later, there was improvement in the EF and GLS with significant difference between the two groups regarding the GLS, E/e` ratio and E/(e`x s`) ratio with a P value of 0.03, <0.001and <0.001 respectively. Multivariate analysis showed that GLS after revascularization and both E/(e`x s`) ratio immediately and 3 months after revascularization were the most powerful predictors for MACE. The optimal cut-off for E/(e`×s`) to predict MACE was 1.72 Conclusion: Pharmaco-invasive PCI constitutes a reliable reperfusion strategy for patients presenting with anterior STEMI | ||
| Keywords | ||
| Primary PCI; Pharmaco-invasive PCI; Systo-diastolic recovery; anterior STEMI | ||
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