Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy | ||
| Suez Canal University Medical Journal | ||
| Article 12, Volume 26, Issue 4, April 2023, Pages 0-0 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/scumj.2023.306591 | ||
| Authors | ||
| Amr S. Mohammed* ; Diaa Eldin M. ElHennawi; Mohamed T. El-Tabbakh; Omnia E. Kilany; Ahmed R. Gardouh | ||
| Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt | ||
| Abstract | ||
| Background: Mucoadhesive nasal gel provides a good platform for drug delivery to the nasal mucosa. We aimedto detect the histologic effect of Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experiment Animals. Light and transmission electron microscopy. Methods:Thirty-six mature male rabbits were placed into three groups. Non-diseased subjects receive intranasal mucoadhesive gel in the vehicle control group. The non-diseased group received intranasal Neomycin-loaded mucoadhesive gel. The non-diseased group receives intranasal ciprofloxacin-loaded mucoadhesive gel. Toluidine blue was used to stain a section of the nasal mucosa for Light and transmission electron microscopy.Results:There is a statistically insignificant difference in histological changes between the Neomycin group and Ciprofloxacin group regarding ciliated, partially deciliated cells, Goblet cells, and variable stain (P.>0.05). Conclusion: Because the antibiotic-loaded mucoadhesive gel caused little harm while preserving the nasal mucosa's integrity, it might be deemed a safe vehicle for administering topical antibiotics. | ||
| Keywords | ||
| Mucoadhesive gel; nanoparticles; antibiotics; nasal mucosa; histopathology | ||
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