Effect of Omega3 in rat stomach induced peptic ulcer by ethanol | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 11 July 2023 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2023.216220.1415 | ||||
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| Authors | ||||
Lamiaa Mohamed Abdallah   ; Ahlam Mohamed Abdallah ; Ahmed Mohamed M.Okasha ; Shereen Samy Gaber ; Hatem A. Mohamed
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| Medical Biochemistry Department, Faculty of Medicine - Minia University | ||||
| Abstract | ||||
| Alcohol intake and physiological stress are major causes of gastric ulcer (GU). The pathophysiology of ethanol-induced GU in animals is similar to that of a human ulcer, Aim of the study; to identify the part omega-3 plays in peptic ulcer and cytokines . TNF-α , IL- β.-.Basic procedures; Sixty white male albino rats weighing an average of 160 g were used in this experiment. Six groups of rats with the same number of animals each were created. The rats were separated into six groups with the same number of animals. After fasting for 18 hours and having access to water, rats were administered ethanol to induce stomach ulcers. Absolute ethanol 95% at the dose level of (0.5 ml/100 g rat) caused stomach ulcers when administered orally. Main findings: The ulcerated control group had significantly higher levels of. TNF-α , IL- β. than Omega-3-treated rats. . TNF-α , IL- β.- levels were considerably lower in rats given Omega-3. Principle conclusion: In both the early and late ulcer groups, serum IL-1B and TNF- α levels were considerably greater compared to the control group, In contrast to the group with ulcers, the protected group had a significant reduction.. Furthermore, in models of ethanol-induced gastric ulcers, oral therapy with omega-3 has been shown to have considerable gastroprotective benefits. | ||||
| Keywords | ||||
| Omega3, Peptic ulcer. TNF-α , IL- &beta | ||||
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