The potential anti-inflammatory and anti-apoptotic influence of hydrogen sulfide on xenoestrogen induced-toxicity in rats | ||
| Benha Veterinary Medical Journal | ||
| Volume 44, Issue 2, July 2023, Pages 41-44 PDF (943.62 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bvmj.2023.206008.1651 | ||
| Authors | ||
| Hind Ahmed Hassan* 1; Omayma A. R. Abo Zaid* 1; Fatma S. M. Moawed* 2; Enas M. Moustafa* 3 | ||
| 1Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University | ||
| 2Health Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority | ||
| 3Radiation Biology, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority. | ||
| Abstract | ||
| Hydrogen sulphide (H2S) is a gas transmitter that plays a vital role in a variety of physiological and pathological processes. Xenoestrogen (XE) a regularly used manufacturing chemical, has been related to endocrine disruptor. The purpose of this study was to investigate the effects of H2S donor (sodium hydrogen sulfide [NaHS]) on xenoestrogen (XE)-induced toxicity in rats. Twenty four adult female rats were divided into three groups: group I: control group, group II rats were intraperitoneally (IP) injected with XE (150 mg/kg body weight/ day) dissolved in corn oil for 4 weeks, group III rats were IP injected with H2S donor NaHS intraperitoneally (IP) at daily dose of 5 mg/kg body weight/day dissolved in deionized water for 6 weeks and were injected with XE as group II. Biomarkers including lactate dehydrogenase (LDH), Interleukin 6 (IL- 6), inducible nitric oxide synthase (iNOS), hypoxia-inducible factor 1 alpha (HIF 1α), caspase-3 were determined and lymphocytes %.The obtained results revealed that ingroup 3, a significant decrease in serum LDH, lymphocytes %, iNOS, with marked decrease in serum Caspase-3when compared to group II. These results suggest that H2S might ameliorate XE induced-toxicity via its anti-inflammatory and anti-apoptotic effects. | ||
| Keywords | ||
| H2S; Xenoestrogen; iNOS; HIF1-α; Caspase-3 | ||
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