Ameliorating Effects of chrysanthemum Against Capecitabin in Albino Rats | ||||
| Suez Canal Veterinary Medical Journal. SCVMJ | ||||
| Article 16, Volume 28, Issue 1, June 2023, Page 197-205 PDF (1.13 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scvmj.2023.307792 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Jaklin Faheem* 1; Reham Eltarabili2; Kawther El-Hady3; Rania H Abdou3 | ||||
| 1Veterinary Medicine Directorate, North Sinai Governorate | ||||
| 2Department of Bacteriology, Mycology and Immunity, Faculty of Veterinary Medicine, Suez Canal University | ||||
| 3Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Suez Canal University | ||||
| Abstract | ||||
| Our study was carried out to evaluate the effect of Chrysanthemum ethanolic extract on some hematological parameters in the anticancer drug capecitabine (XELODA®) exposed male rats using comet assay and biochemical changes. Thirty-six albino rats were divided into 6 groups (6 animals each) as follows:1) capecitabine group (xeloda at a dose of 30 mg/kg bw as a positive control); 2) capecitabine + chrysanthemum 5 mg/kg); 3) capecitabine (Xeloda) + Chrysanthemum (10 mg/kg); 4) Chrysanthemum (5 mg/kg) 5) Chrysanthemum (10 mg/kg); 6) Control group (negative control) for 45 days. The results of this study led to the following: capecitabine (Xeloda)treatment induces a decrease in RBCS, leukocytes, and platelets count, level of Hgb and Hct, while the use of capecitabine (Xeloda)in combination with Chrysanthemum improved these alterations, especially with the high dose of Chrysanthemum. Finally, the data suggest that the synchronous use of Chrysanthemum with capecitabine (Xeloda) treatment will be useful to decrease the side effects of capecitabine. | ||||
| Keywords | ||||
| Chrysanthemum; capecitabine; hematological parameters | ||||
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