Fabrication of bioactive wound dressing containing carbopol, hyaluronic acid and Na-alginate | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 1, January 2024, Page 343-352 PDF (781.72 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2023.217051.8124 | ||||
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| Authors | ||||
H.M. Fahmy; Moustafa M.G. Fouda ; A. Amr ; A. Abou-Okeil 
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| Textile Research and Technology Institute, National Research Center, Cairo, Egypt. | ||||
| Abstract | ||||
| Novel wound dressings were prepared by treating non-woven cotton fabric samples with different formulations of carbopol (CP), hyaluronic acid (HA), and sodium alginate (HA) followed by crosslinking with Ca2+, Zn2+ or Cu2+ ions. The impacts of such formulations on the antibacterial besides, some physico-mechanical properties of such dressings were studied. Loading the crosslinked CP/HA/SA dressing with sodium diclofenac and its in-vitro releasing from that dressing at pH 7 was investigated. To improve the antibacterial activities of such dressing, silver nano-particles were incorporated as a bioactive agent in the dressing formulation. The CP/HA/SA crosslinked film was characterized via FTIR analysis whereas the CP/HA/SA dressing SEM and EDX images were investigated. | ||||
| Keywords | ||||
| Wound dressing; Carbopol; Hyaluronic acid; Sodium alginate; Metal ions | ||||
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