Toxic and Teratogenic Effects of Sampa-Sampalukan (Phyllanthus niruri) Leaves Extract Using Danio rerio Embryo Assay | ||
| Egyptian Academic Journal of Biological Sciences, B. Zoology | ||
| Article 11, Volume 11, Issue 1, June 2019, Pages 109-115 PDF (927.92 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsz.2019.30839 | ||
| Authors | ||
| I. Q. Lamban1; E. S. Balbeuna1; M. Y. S. Lee2; M. Sacdalan2; A. P. arpio JR.2; Kevin Smith P. Cabuhat3 | ||
| 1Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bulacan, Philippines | ||
| 2Department of Biology, College of Science, Bulacan State University, City of Malolos, Bulacan, Philippines | ||
| 3AD-DRUGSTEL Pharmaceutical Laboratories Incorporation, First Bulacan Industrial City, Tikay, Malolos, Bulacan, Philippines | ||
| Abstract | ||
| This paper established toxic and teratogenic effects of P. nururi leaves extract to the embryonic development of D. rerio. After 12 hours of exposure to various treatment concentrations, 100% coagulated embryos were observed in 1% and higher concentrations. Meanwhile, mortality in lower concentrations was found to be as time and dose-dependent. Coagulation was the most remarkable toxic effect of the plant leaves extract. On the other hand, heartbeat and hatchability rate of zebrafish embryo was affected in a dose-dependent manner. In teratogenicity testing, tail malformation was the most evident teratogenic effect of the plant leaves extract. Taken together, P. niruri leaves extract was embryo-toxic and teratogenic to D. rerio. | ||
| Keywords | ||
| Danio rerio; embryo-toxicity; Phyllanthus niruri; Sampa-sampalukan; teratogenicity; zebrafish | ||
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