Correlation between Anti‐DNA/N‐methyl‐D‐aspartate Receptor 2 antibodies and Systemic Lupus Erythematosus
M.Bhnasawy, M., H.Ibrahim, N., M.Fawzy, R., M.El Sayed, R., Sh.El-Brashy, A. (2023). Correlation between Anti‐DNA/N‐methyl‐D‐aspartate Receptor 2 antibodies and Systemic Lupus Erythematosus. EKB Journal Management System, 8(3), 68-71. doi: 10.21608/bjas.2023.203796.1145
Menna M.Bhnasawy; Noha H.Ibrahim; Rasha M.Fawzy; Rasha M.El Sayed; Abd-El Wahab Sh.El-Brashy. "Correlation between Anti‐DNA/N‐methyl‐D‐aspartate Receptor 2 antibodies and Systemic Lupus Erythematosus". EKB Journal Management System, 8, 3, 2023, 68-71. doi: 10.21608/bjas.2023.203796.1145
M.Bhnasawy, M., H.Ibrahim, N., M.Fawzy, R., M.El Sayed, R., Sh.El-Brashy, A. (2023). 'Correlation between Anti‐DNA/N‐methyl‐D‐aspartate Receptor 2 antibodies and Systemic Lupus Erythematosus', EKB Journal Management System, 8(3), pp. 68-71. doi: 10.21608/bjas.2023.203796.1145
M.Bhnasawy, M., H.Ibrahim, N., M.Fawzy, R., M.El Sayed, R., Sh.El-Brashy, A. Correlation between Anti‐DNA/N‐methyl‐D‐aspartate Receptor 2 antibodies and Systemic Lupus Erythematosus. EKB Journal Management System, 2023; 8(3): 68-71. doi: 10.21608/bjas.2023.203796.1145

Correlation between Anti‐DNA/N‐methyl‐D‐aspartate Receptor 2 antibodies and Systemic Lupus Erythematosus

Benha Journal of Applied Sciences
Article 11, Volume 8, Issue 3, March 2023, Page 68-71  XML PDF (398.14 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2023.203796.1145
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Authors
Menna M.Bhnasawy email 1; Noha H.Ibrahim1; Rasha M.Fawzy1; Rasha M.El Sayed1; Abd-El Wahab Sh.El-Brashy2
1Rheumatology&Rehabilitation Dept., Fac., of Medicine, Benha Univ., Egypt
2Sh.El-Brashy
Abstract
Background:Self-reactive antibodies are a characteristic of systemic lupus erythematosus [SLE]. These autoantibodies may attack any organ or tissue in the body causing organ failure. One class of anti-DNA antibodies, known as anti-DNA/N-methyl-D-aspartate receptor 2 [anti-DNA/NR2] antibodies, also interacts with the NR2 subunit [anti-NR2] of N-methyl-D-aspartate receptors [NMDARs]. Research suggests that anti-NMDAR antibodies contribute to the pathophysiology of SLE-related emotional and cognitive dysfunction.Objective:The goal of this study was to evaluate the prevalence and severity of systemic lupus erythematosus in individuals with anti-DNA/N-methyl-D-aspartate receptor 2 [NR2] antibodies.Methodology: 60 SLE patients and 30 healthy controls had serum samples taken. Anti-NR2 antibodies in the serum were tested using an ELISA kit.Results: The average serum anti-NR2 antibody level in SLE patients was 34.10 ng/ml, whereas the level in healthy controls was only 11.60 ng/ml with a statistically significant difference [P<0.001].Serum anti-NR2 can significantlydiscriminate between SLE patients and healthy subjects, with diagnostic ability at best cut off value 13.26 ng/ml with high sensitivity and specificity.Conclusion:Serum anti-NR2 can be used as a new biomarker for SLE.
Keywords
anti‐DNA/N‐methyl‐D‐aspartate receptor 2 antibodies; Systemic lupus erythematosus; Biomarker
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