Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study | ||||
| Suez Canal University Medical Journal | ||||
| Article 6, Volume 26, Issue 6, June 2023, Page 0-0 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2023.308792 | ||||
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| Authors | ||||
| Walaa S. Ali* ; Ehab M. Hasanin; Maha L. Zamzam; Sharehan H. Soliman | ||||
| Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University | ||||
| Abstract | ||||
| Background: Head and neck cancers are the sixth most common malignancy in the world, with unacceptably high mortality rates in developing countries. More than 90% of these cancers are squamous cell carcinomas (SCCs) and variants, originating from the epithelium of the mucosal lining of the upper aerodigestive tract. Aim: To evaluate the role of induction chemotherapy before concurrent chemoradiotherapy in the treatment of locally advanced non-metastatic (stage III or IV A, B) squamous cell carcinoma of laryngeal & nasopharyngeal cancers regarding progression-free survival, disease-free survival, toxicity, and organ preservation (laryngeal cancer). Patients and Methods: This is a retrospective study was conducted to estimate the value of induction chemotherapy followed by concurrent chemoradiation for locally advanced non-metastatic (stage III or IVA, B) squamous cell carcinoma of larynx & nasopharynx patients, attending Clinical Oncology Department, Suez Canal University Hospital, Ismailia, Egypt during the period from 1/2017 to 12\2018 &follow up period from 1/2019 to 12/2020. Results: This study revealed that there was no statistical significance in disease-free survival between the two groups. Regarding progression-free survival, there was a statistically significant in the Induction Chemotherapy followed by chemoradiotherapy, compared to chemoradiotherapy alone. Conclusion: Induction chemotherapy by TPF or PF is a reasonable approach for locally advanced non-metastatic nasopharyngeal and laryngeal squamous cell carcinoma as it gives better results in post-radiotherapy assessment for laryngeal cancers, and progression-free survival for both laryngeal and nasopharyngeal cancer patients. | ||||
| Keywords | ||||
| Squamous Cell Carcinomas; Concurrent Chemoradiation; Laryngeal & Nasopharyngeal Cancers | ||||
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