Evaluation of the Role of Platelet-Rich Fibrin (PRF) in the Management of Mandibular Bony Cysts after Surgical Enucleation | ||||
| Suez Canal University Medical Journal | ||||
| Article 1, Volume 26, Issue 6, June 2023, Page 1-8 PDF (261.13 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2023.308797 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amr A. Gomaa; Ahmed El said  ; Mohamed A. El Badawy; Ahmad E. Mohamed
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| Department of Plastic Surgery, Faculty of Medicine, Suez Canal University, Egypt | ||||
| Abstract | ||||
| Background: Cystic mandibular lesions may be epithelial or non-epithelial, odontogenic, or non-odontogenic, developmental, or inflammatory in origin. Clinically bony cysts are usually asymptomatic and are often accidentally discovered on routine radiological examination. PRF has been shown to act as a suitable scaffold for culturing human periosteal cells in vitro, which may be suitable for bone tissue engineering applications. Aim: This study aimed to explore the clinical and radiographic effectiveness of autologous PRF in the treatment of intrabony cyst cavity after enucleation. Subjects and Methods: The present study was designed as a randomized controlled clinical trial that included patients with mandibular bony cysts as well as benign tumors of the mandibular surgery department at Suez Canal University Hospital and Suez Health Insurance Hospital. The study participants were randomly divided into two groups: i) the study group who underwent enucleation of the cysts then PRF was added and ii) the Control group who underwent enucleation of the cysts only. Results: In the control group, the mesiodistal length of the cyst at 6 months after enucleation (2.53 ± 1.74) was significantly lower than that length just after operation (3.03 ± 1.93) (p < 0.001). However, there was no statistically significant difference in mesiodistal length of the cyst just after the operation (3.03 ± 1.93) and 2 months after enucleation (2.98 ± 1.96). Meanwhile, in the PRF group, the mesiodistal length of the cyst just after the operation (3.17 ± 1.89) was significantly lower than that length at 2 and 6 months after enucleation (2.20 ± 1.35) and (1.43 ± 1.44) (p < 0.001).Patients who received PRF had significantly lower 6 months from baseline change in each mesiodistal length (p=0.001) and superior-inferior length (p=0.002) than patients in the control group. Conclusion: PRF promotes faster osseous regeneration in the Management of mandibular bony Cysts after Surgical Enucleation. The use of PRF in the management of cystic lesions seems to be a novel therapeutic approach promoting faster osseous regeneration. | ||||
| Keywords | ||||
| Platelet-Rich Fibrin (PRF); Mandibular Bony Cysts; Surgical Enucleation | ||||
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