Naringin Attenuates D-galactose-Induced Brain Aging Via Regulation Of Oxidative Stress Markers TNF-α, NF-κβ And Modulation Of The Neurotrophic Markers PGC1-α, NT-3 AGEs, And GFAP In Vivo
Salama, A., sadek, S., El Shahed, Z. (2024). Naringin Attenuates D-galactose-Induced Brain Aging Via Regulation Of Oxidative Stress Markers TNF-α, NF-κβ And Modulation Of The Neurotrophic Markers PGC1-α, NT-3 AGEs, And GFAP In Vivo. EKB Journal Management System, 67(2), 1-15. doi: 10.21608/ejchem.2023.212559.8002
Abeer Salama; shaimaa A. sadek; Zeinab Abd Elkhalek El Shahed. "Naringin Attenuates D-galactose-Induced Brain Aging Via Regulation Of Oxidative Stress Markers TNF-α, NF-κβ And Modulation Of The Neurotrophic Markers PGC1-α, NT-3 AGEs, And GFAP In Vivo". EKB Journal Management System, 67, 2, 2024, 1-15. doi: 10.21608/ejchem.2023.212559.8002
Salama, A., sadek, S., El Shahed, Z. (2024). 'Naringin Attenuates D-galactose-Induced Brain Aging Via Regulation Of Oxidative Stress Markers TNF-α, NF-κβ And Modulation Of The Neurotrophic Markers PGC1-α, NT-3 AGEs, And GFAP In Vivo', EKB Journal Management System, 67(2), pp. 1-15. doi: 10.21608/ejchem.2023.212559.8002
Salama, A., sadek, S., El Shahed, Z. Naringin Attenuates D-galactose-Induced Brain Aging Via Regulation Of Oxidative Stress Markers TNF-α, NF-κβ And Modulation Of The Neurotrophic Markers PGC1-α, NT-3 AGEs, And GFAP In Vivo. EKB Journal Management System, 2024; 67(2): 1-15. doi: 10.21608/ejchem.2023.212559.8002

Naringin Attenuates D-galactose-Induced Brain Aging Via Regulation Of Oxidative Stress Markers TNF-α, NF-κβ And Modulation Of The Neurotrophic Markers PGC1-α, NT-3 AGEs, And GFAP In Vivo

Egyptian Journal of Chemistry
Volume 67, Issue 2, February 2024, Page 1-15  XML PDF (1.93 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.212559.8002
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Authors
Abeer Salamaorcid 1; shaimaa A. sadekorcid 2; Zeinab Abd Elkhalek El Shahed email orcid 3
1pharmacology, NRC
2Medical Biochemistry Department, National Research Centre
3National research center
Abstract
Abstract

Aging is a global issue that we all deal with on a daily basis. The level of reliance among elderly persons everywhere increases as a result of brain aging and cognitive dysfunction. Naringin is a natural compound that showed various medicinal applications and is commonly used as an anticancer, antioxidant, and anti-inflammatory properties. The current research evaluated naringin infleunce on D-galactose (D-gal) stimulated brain aging in vivo. Mice were distriputed randomely to 4 groups (10 mice/ group): Normal group, D-gal group, Groups 3& 4: Naringin (150&300 mg/kg; orally) concurrent with D-gal for 8 weeks. Behavioral, brain biochemical, and histopathological changes were assessed. Results: Naringin treatment increased rate of discrimination in recognizing of objects , Y Maze percent fluctuation, locomotive activity, and brain levels of AMPK, LKB1, PGC1-α, nerve growth factor (neurotrophin-3; NT-3), dopamine, and serotonin with a significant decrement of brain contents of TNF-α, NF-κβ, AGEs, and GFAP compared to D-gal-treated mice. In addition, naringin ameliorated neuron degeneration. In conclusion, naringin ,with its anti-inflammatory effects , has stimulated mitochondrial biogenesis and modulated neurotrophic factors and neurotransmitters regulating nerve regeneration. Yet , naringin could be a promising drug with potential neuroprotective action against brain aging stimulated neurodegeneration.
Keywords
Naringin; Aging; AGEs; GFAP; NT3
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