Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent
Mohamed, A., Ayad, D., Al-Subbagh, H., Abdelaal, M. (2024). Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent. EKB Journal Management System, 67(2), 487-495. doi: 10.21608/ejchem.2023.214817.8068
Ayda A. Mohamed; D.M. Ayad; H. Al-Subbagh; M.Y. Abdelaal. "Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent". EKB Journal Management System, 67, 2, 2024, 487-495. doi: 10.21608/ejchem.2023.214817.8068
Mohamed, A., Ayad, D., Al-Subbagh, H., Abdelaal, M. (2024). 'Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent', EKB Journal Management System, 67(2), pp. 487-495. doi: 10.21608/ejchem.2023.214817.8068
Mohamed, A., Ayad, D., Al-Subbagh, H., Abdelaal, M. Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent. EKB Journal Management System, 2024; 67(2): 487-495. doi: 10.21608/ejchem.2023.214817.8068

Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent

Egyptian Journal of Chemistry
Volume 67, Issue 2, February 2024, Pages 487-495    PDF (634.38 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2023.214817.8068
Authors
Ayda A. Mohamed* 1, 2; D.M. Ayad1; H. Al-Subbagh3; M.Y. Abdelaal1
1Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt
2Faculty of Pharmacy, Horus University in Egypt, New Damietta, Egypt
3Medicinal Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt
Abstract
In the current work, 4-nitroaniline (1) reacted with sodium azide to produce 4-nitrophenyl azide (2) and converted into the corresponding 1,2,3-triazole derivative (3). The obtained 1,2,3-triazole derivative (3) converted into (E)-1-[5-methyl-1-(4-nitrophenyl)triazol-4-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (4) through Claisen-Schmidt condensation with 3,4,5-trihydroxybenzaldehyde in ethanolic NaOH. Compound 4 was then characterized with the suitable spectroscopic techniques and investigated for its anticancer activity. Blends of 4 with Chitosan (CS) and carboxymethylcellulose (CMC) were prepared by uploading it into the polymer matrices through physical mixing. The release behavior of 4 from the polymer blends into an aqueous medium at room temperature was investigated and discussed.
Keywords
1,2,3-triazole chalcone hybrid; Anticancer activity; Chitosan; CMC; Controlled release
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