Utilization of polymeric carriers for (E)-1-(5-methyl-1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one as anticancer agent | ||
| Egyptian Journal of Chemistry | ||
| Volume 67, Issue 2, February 2024, Pages 487-495 PDF (634.38 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.214817.8068 | ||
| Authors | ||
| Ayda A. Mohamed* 1, 2; D.M. Ayad1; H. Al-Subbagh3; M.Y. Abdelaal1 | ||
| 1Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt | ||
| 2Faculty of Pharmacy, Horus University in Egypt, New Damietta, Egypt | ||
| 3Medicinal Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| In the current work, 4-nitroaniline (1) reacted with sodium azide to produce 4-nitrophenyl azide (2) and converted into the corresponding 1,2,3-triazole derivative (3). The obtained 1,2,3-triazole derivative (3) converted into (E)-1-[5-methyl-1-(4-nitrophenyl)triazol-4-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (4) through Claisen-Schmidt condensation with 3,4,5-trihydroxybenzaldehyde in ethanolic NaOH. Compound 4 was then characterized with the suitable spectroscopic techniques and investigated for its anticancer activity. Blends of 4 with Chitosan (CS) and carboxymethylcellulose (CMC) were prepared by uploading it into the polymer matrices through physical mixing. The release behavior of 4 from the polymer blends into an aqueous medium at room temperature was investigated and discussed. | ||
| Keywords | ||
| 1,2,3-triazole chalcone hybrid; Anticancer activity; Chitosan; CMC; Controlled release | ||
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