Clinical and laboratory predictors of isolated coronary artery ectasia in patients with chronic coronary syndromes

Mahmoud, Khalid Sayed; Abdelnaem, Emad Allam; Ali Tony, Tarek Yehia; Senosy, Tarek Mahmoud; Atta, Ashraf Radi; Setohi, Amr Mustafa Abdelhafez

doi:10.21608/mjmr.2023.215089.1407

	Clinical and laboratory predictors of isolated coronary artery ectasia in patients with chronic coronary syndromes
Minia Journal of Medical Research
Articles in Press, Accepted Manuscript, Available Online from 21 August 2023
Document Type: Original Article
DOI: 10.21608/mjmr.2023.215089.1407
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Authors
Khalid Sayed Mahmoud¹; Emad Allam Abdelnaem²; Tarek Yehia Ali Tony ¹; Tarek Mahmoud Senosy¹; Ashraf Radi Atta¹; Amr Mustafa Abdelhafez Setohi¹
¹Cardiology Department, Faculty of Medicine, Minia University, Minia, Egypt
²Clinical pathology Department, Faculty of Medicine, Minia university, Minia, Egypt
Abstract
Background: Coronary artery ectasia (CAE)is a dilatation of coronary arteries that can cause acute coronary syndrome (ACS), its causes and pathophysiology are not cleared yet, however, many postulations existed including; endothelial dysfunction, micro-vascular disease, oxidative stress, inflammation, enhanced platelet activity and exaggerated positive vascular remodelling. Methods: Our study highlights some of the predictors for CAE such as Big Endothelin-1(BigET-1), High sensitive CRP (hs-CRP), Neutrophils to lymphocytic count ratio(NLR), LDL/HDL ratio, and ALT/AST Ratio. Results: 100 patients are included in this study. patients were categorized into four equal-sized groups, 25 patients with isolated CAE, 25 patients with both obstructive CAD and CAE, 25 patients with obstructive CAD only, and 25 patients with normal CA( control group). Our study showed that the Big Endothelin-1(BigET-1)( P=0.001), High sensitive CRP (hs‑CRP)( P=0.001), LDL/HDL ratio(P=0.006) were significant predictors of CAE, Others as Neutrophils to lymphocytic count ratio(NLR)( P=0.09), ALT/AST Ratio (P=0.08)were not significant predictors of CAE. Conclusions: A higher level of BigET-1, hs‑CRP, and LDL/HDL Ratio were predictors independently associated with CAE patients. These markers level may therefore provide diagnostic information for CAE patients
Keywords
Big Endothelin-1(BigET-1); High sensitive CRP (hs‑CRP); LDL/HDL ratio; NLR; ALT/AST Ratio


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