The Significance of Expression of MUC 4 and IMP-3 in Benign Prostatic Hyperplasia, High Grade Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma(immunohistochemical study) | ||
| Benha Medical Journal | ||
| Article 14, Volume 40, Issue 2, September and October 2023, Pages 462-473 PDF (778.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2023.203221.1795 | ||
| Authors | ||
| Zeinab Ibrahim Elshawarby1; kareem Ali El Attar2; naglaa hamed shalan* 3 | ||
| 1pathology,faculty of medicie,Benha university,Egypt | ||
| 2urology department,benha faculty of medicine,benha university,benha, Egypt | ||
| 3pathology.faculty of medicine,Benha university,Benha | ||
| Abstract | ||
| Background : Prostate cancer is one of the most frequent malignancy worldwide . Mucin 4(MUC4) is a transmembrane mucin that is contributed in cell signalling events that guide the proliferation of cells. Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been linked to tumorgenesis and progression of many cancers. Aim: This study aimed to evaluate MUC4 and IMP-3 expression in different prostatic lesions and to relate the results with clinicopathological data. Material & method: This retrospective study examined 40 cases including10 cases of benign prostatic hyperplasia (BPH), 6 cases of high-grade prostatic intraepithelial neoplasia (HGPIN) and 24 cases of prostatic adenocarcinoma (PCa) . MUC 4 and IMP-3 were used for the immunohistochemistry. Results: MUC4 was detected in (100%) of BPH & HGPIN cases and (16.6%) of prostatic carcinoma.IMP3 expressed in (100%) of prostatic cancer cases and expressed in(10%) &(16.7%) of &HGPIN respectively. A significant statistical correlations between IMP3expression and stage, Gleason’s grade ,pre OP serum PSA level>10ng/ml, capsular and perineural invasion(P | ||
| Keywords | ||
| MUC4; IMP3.BPH; Prostatic adenocarcinoma | ||
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