A Bayesian Approach for Estimating Twin Similarity with Respect to a Binary Trait Under the Beta-Binomial Model
Ahmed, M., Shoukri, M. (2011). A Bayesian Approach for Estimating Twin Similarity with Respect to a Binary Trait Under the Beta-Binomial Model. EKB Journal Management System, 55(1), 10-21. doi: 10.21608/esju.2011.314308
Marwa Ahmed; Mohamed Shoukri. "A Bayesian Approach for Estimating Twin Similarity with Respect to a Binary Trait Under the Beta-Binomial Model". EKB Journal Management System, 55, 1, 2011, 10-21. doi: 10.21608/esju.2011.314308
Ahmed, M., Shoukri, M. (2011). 'A Bayesian Approach for Estimating Twin Similarity with Respect to a Binary Trait Under the Beta-Binomial Model', EKB Journal Management System, 55(1), pp. 10-21. doi: 10.21608/esju.2011.314308
Ahmed, M., Shoukri, M. A Bayesian Approach for Estimating Twin Similarity with Respect to a Binary Trait Under the Beta-Binomial Model. EKB Journal Management System, 2011; 55(1): 10-21. doi: 10.21608/esju.2011.314308

A Bayesian Approach for Estimating Twin Similarity with Respect to a Binary Trait Under the Beta-Binomial Model

The Egyptian Statistical Journal
Article 2, Volume 55, Issue 1, June 2011, Pages 10-21    PDF (16.18 M)
Document Type: Original Article
DOI: 10.21608/esju.2011.314308
Authors
Marwa Ahmed1; Mohamed Shoukri2
1Faculty of Graduate Studies and Statistical Research, Cairo University
2Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Sepecialist Hospital and Research Center, Riyadh, Saudi Arabia.
Abstract
In twin studies there is a need to compare a sample of monozygotic to another independent sample of dizygotic twins with respect to the presence or absence of a specific disease or condition. A significant difference between the intracluster correlation coefficients between the two independent samples indicates the presence of a genetic component in the disease etiology, and is an estimate of twin similarity. In this paper, Bayesian statistical methodology is presented for the estimation of twin similarity with respect to a dichotomous trait. The parameter of interest is the difference between the intracluster correlation coefficients (ICC) of the two zygosity groups. Under the Beta- Binomial model, point and interval estimators for this difference, 4, are obtained.
 
Keywords
Beta; Binomial Model; Interval Estimation; Intracluster Correlation
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