Bone Mineral Density in Female Patients with Rheumatoid Arthritis in Relation to Anti-Cyclic Citrullinated Peptide Antibody and Rheumatoid Factor | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 143, Volume 92, Issue 1, July 2023, Page 6403-6412 PDF (708.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.314503 | ||||
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| Abstract | ||||
| Background: Rheumatoid arthritis (RA) is an autoimmune disorder associated with a chronic inflammation, which can cause joint damage and extra-articular complications. Anti-citrullinated protein antibody (ACPA) positivity is accompanied by poor prognosis in RA, and testing for ACPA has become traditional practice in the context of RA diagnosis. Objective: The aim of the study was to estimate the prevalence of lowbone mineral density (BMD) among female patients with RA using dual energy x-ray absorptiometry (DEXA), and to study the correlation between BMD & levels of anti-cyclic citrullinated peptide (anti-CCP) and RF in the studied cases. Patients and methods: The present study was a cross-section descriptive study that was conducted on eighty female patients with RA. All patients were subjected to assessment to the levels of anti-CCP and RF using ELISA. BMD was measured by DEXA. Results: Osteopenia and Osteoporosis at lumbar spine, femoral neck and distal end of radius showed statistically significant increase in +ve anti-CCP patients when compared to –ve anti-CCP patients. BMD at the lumbar spine, femoral neck and lower end of radius showed statistically significant decrease in +ve anti-CCP patients when compared to –ve anti-CCP patients. History of fragility fracture showed statistically significant increase in RA patients with +ve RF when compared to -ve RF patients. Conclusion: Bone loss and fragility fracture are common in RA and increased in seropositive RA, post-menopausal state and corticosteroids use. The presence of ACPA and RF are strongly predictive for the development of osteoporosis and erosions in RA patients. It would be a more appropriate approach to carefully monitor osteoporosis in seropositive RA. | ||||
| Keywords | ||||
| ti-CCP; Rheumatoid factor; Rheumatoid arthritis; Dual energy X-ray absorptiometry | ||||
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