Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms | ||
| Benha Medical Journal | ||
| Article 19, Volume 40, Issue 2, September and October 2023, Pages 516-527 PDF (1.48 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2023.223495.1854 | ||
| Authors | ||
| Omneya Bassyoni* 1; Zeinab Elshawarby2; Ahmed Abostate3 | ||
| 1department of pathology ,faculty of medicine ,Benha univeristy ,Benha ,Egypt | ||
| 2Department of Pathology, faculty of medicine, benha university, benha, egypt | ||
| 3department of general surgery , faculty of medicine ,Benha univeristy ,Egypt | ||
| Abstract | ||
| OBJECTIVE : Papillary breast neoplasms are heterogenous group of diseases consisting of wide range of benign, atypical and malignant lesions . Evaluation of such papillary neoplasms is considered one of the most problematic issues in diagnosis of breast pathology depending on H&E only as they need different treatment options. Aim: To differentiate papillary breast lesions depending on immunohistochemical staining of P63, SMA, CK14, chromogranin and ER. MATERIAL AND METHODS: An immunohistochemical profile using 5 markers were conducted on 75 papillary breast neoplasms. RESULTS: Out of 75 cases, 100% of duct papillomas were positive to P63& SMA. CK14 was positive in 90% of papilloma compared to malignant lesions : DCIS , intracystic papillary carcinomas , solid papillary carcinomas which were negative (84.0% , 92.3 % , 90.0% & 100.0% ,respectively ) .Solid papillary carcinomas were positive for chromgranin. .In 90% of DCIS , 92.3% intracystic papillary carcinomas , 90.0% solid papillary carcinomas and 100% of invasive micropapillary carcinomas- ER was homogenous positive compared to papillomas with heterogenous expression with statistical significant correlation (P | ||
| Keywords | ||
| Breast; Papilloma; Carcinoma | ||
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