Ginger and Atorvastatin Attenuates Diazinon Induced Nephrotoxicity | ||
| Benha Journal of Applied Sciences | ||
| Article 28, Volume 8, Issue 5, May 2023, Pages 337-346 PDF (1.18 M) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2023.201220.1126 | ||
| Authors | ||
| Rania Elshafae1; Ashraf Elkomy1; Enas Farrag2; Said Elshafae* 3; Mohamed Aboubakr4 | ||
| 1Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt | ||
| 2Animal Health Research Institute for Regional Laboratories | ||
| 3Department of Pathology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt. | ||
| 4Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, Toukh 13736, Egypt. | ||
| Abstract | ||
| Diazinon (DZ) is an organophosphorus class II pesticide that is broadly used in agricultural fields and household environments. Ginger (GE) and Atorvastatin (AT) have been shown to have potent anti-oxidative, anti-inflammatory and anti-apoptotic properties in some animal models of toxicity. Here, we investigated the protective properties of GE and AT on DZ-induced renal damage in rats. Total of seven rat groups (7 rats/group) received saline solution (control), ginger (GE), Atorvastatin (AT), Diazinon (DZ), DZ/GE, DZ/AT and DZ/GE/AT through gavage once per day for 30 days respectively. Blood were collected and sera were separated for analysis of kidney failure parameters (Urea and Creatinine). Anti-oxidation parameters were also measured in all the kidneys. Histopathology and IHC of cleaved caspase 3 were also performed on the renal tissues of different groups. Our results showed that GE and AT attenuated DZ-induced renal damage by reduction of malondialdehyde (MDA) and apoptotic (cleaved caspase-3) markers and improving the level of antioxidants and histological picture. Overall, the protective effects of GE and ATR on DZ-induced nephrotoxicity was prominent in DZ intoxicated rats co-treated with one or both compounds and this could be attributed to their potent antioxidative, anti-inflammatory and antiapoptotic properties. | ||
| Keywords | ||
| Kidney; Ginger; Atorvastatin; Diazinon; Nephrotoxicity | ||
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