Assessment of Macular & Peripapillary Microvasculature Using Optical Coherence Tomography-Angiography in Primary Open-Angle Glaucoma Patients | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 161, Volume 92, Issue 1, July 2023, Page 6527-6534 PDF (405.85 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.316241 | ||||
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| Abstract | ||||
| Background: Glaucoma pathogenesis is related to vascular affection. Optical coherence tomography-angiography (OCT-A) is the latest noninvasive imaging techniques for studying the retinal vasculature, optic nerve, and peripapillary region. Glaucoma is related to the reduction of ocular blood flow. Objective: Assessment of the retinal microvasculature changes including the vascular density of macular and radial peripapillary capillary (RPC) in eyes with primary open-angle glaucoma (POAG) using OCT-A. Subjects and Methods: The study included 44 eyes that were divided into two groups. Group 1 included22 eyes healthy subjects as control group and group 2 that contained22 eyes of POAG patients. All were subjected to history, complete ophthalmological examination including refraction, BCVA, slit-lamp, indirect ophthalmoscopy, gonioscopy, applanation tonometry. Investigations were applied; Visual Field (Carl Zeiss Humphrey A3), OCT, retinal nerve fiber layer thinning (RNFLT) & ganglion cell complex (GCC) thickness. (Triton, Topcon) and study tool Swept-Source OCT-A. (Triton, Topcon). Quantitative analysis software; GNU Image Manipulation Program (GIMP). Program V.2.10.8 software. Results: The results showed a statistically significant decrease in vessel density (VD) in the peripapillary region (P<0.001) and both, superficial (P<0.001) and deep (P=0.001) macular regions in POAG subjects. So, the functional damage (VD) was associated with more pronounced structural damage (RNFLT, GCC). Conclusion: The peripapillary and superficial macular VD outperformed the deep macular VD, as a diagnostic test differentiating between POAG and healthy eyes. The present study found the OCT-A assessment of peripapillary, and macular VD have a good value in monitoring of microcirculation changes in POAG & explaining the relationship between ocular microcirculation and glaucoma pathophysiology. | ||||
| Keywords | ||||
| Primary open angle glaucoma; Optical coherence tomography-angiography | ||||
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