Study of the Effectiveness of Cervical Cerclage Versus Progesterone in Preterm Labor. A Comparative Clinical Trial | ||
| Zagazig University Medical Journal | ||
| Article 29, Volume 30, Issue 1.3, March and April 2024, Pages 238-247 PDF (1.11 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2023.231989.2862 | ||
| Authors | ||
| Anwer Ezzat Ismail1; Walid Abdallah2; Hudi Alshareef Thabit* 3; Wafaa Mohamed Diab4 | ||
| 1Obstetrics & Gynecology faculty of medicine Zagazig unversity Egypt | ||
| 2Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt | ||
| 3MBCCH, Faculty of Medicine, Benghazi- University -Libya | ||
| 4Department, Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt | ||
| Abstract | ||
| Background: Patients with a singleton pregnancy, a history of spontaneous preterm delivery, and a short cervix may benefit from preterm birth prevention strategies that involve vaginal progesterone treatment as well as the placement of a cervical cerclage. Aim: comparing the efficacy of using both vaginal and intramuscular progesterone versus cervical cerclage for prevention of the preterm birth among females with previous history of preterm birth. Methods: One hundred and twenty pregnant females with an increased risk of preterm labor (assessed by a previous preterm birth (PTB) or transvaginal ultrasound (TVUS) findings of a shortened cervix which is less than 25 mm participated in this randomized controlled study at the Obstetrics and Gynecological Department of Zagazig University Hospital. Group A: 62 pregnant women had progesterone therapy in the form of vaginal suppositories 400mg twice per day and intramuscular long-acting progesterone per week at 13 weeks to 37 weeks gestational age. Group B: (Cervical Cerclage group) 58 pregnant women who had Cervical Cerclage at 13 weeks gestation without progesterone. Results: Cervical length is significantly increased in the cerclage group from 1.877+.41 cm to 2.18+.31 cm with P value <0.001 after doing the cerclage. When compared to the cervical cerclage, progesterone use yielded similar effects with non-statistically significant differences in terms of method of delivery, pregnancy fate, and neonatal outcomes. Conclusion: The progesterone is successful as cervical cerclage in preventing preterm labor but its usage could be better in clinical as it's noninvasive method and economic | ||
| Keywords | ||
| Cervical Cerclage; Progesterone; Preterm Labor | ||
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