Effect of soybean on some biochemical markers and histopathological changes in lead intoxicated rats
A., E., M., W., A., M. (2015). Effect of soybean on some biochemical markers and histopathological changes in lead intoxicated rats. EKB Journal Management System, 29(2), 136-146. doi: 10.21608/bvmj.2015.31685
El senosi Y. A.; Wasfie N. M.; Mustafa S. A.. "Effect of soybean on some biochemical markers and histopathological changes in lead intoxicated rats". EKB Journal Management System, 29, 2, 2015, 136-146. doi: 10.21608/bvmj.2015.31685
A., E., M., W., A., M. (2015). 'Effect of soybean on some biochemical markers and histopathological changes in lead intoxicated rats', EKB Journal Management System, 29(2), pp. 136-146. doi: 10.21608/bvmj.2015.31685
A., E., M., W., A., M. Effect of soybean on some biochemical markers and histopathological changes in lead intoxicated rats. EKB Journal Management System, 2015; 29(2): 136-146. doi: 10.21608/bvmj.2015.31685

Effect of soybean on some biochemical markers and histopathological changes in lead intoxicated rats

Benha Veterinary Medical Journal
Article 16, Volume 29, Issue 2, December 2015, Pages 136-146    PDF (581.95 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2015.31685
Authors
El senosi Y. A.1; Wasfie N. M.1; Mustafa S. A.2
1Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt
2Department of pathology, Faculty of Veterinary Medicine, Benha University, Egypt
Abstract
The protective and treatment effect of dietary soybean against lead toxicity induced changes in the
bones and the hormones of the reproductive system in male rats were investigated, Seventy two adult
male rats were divided into the following groups:Group1:36 rats fed on soya bean free diet were divided
into three equal sub groups:Group1a:control soya bean free diet (-ve), Group1b:rats fed on soya bean
free diet after lead intoxicated (rats injected with lead acetate(8mg/body weight) from 1st week to 4th
week , Group1c: rats fed on soya bean free diet before lead intoxicated (rats injected with lead acetate
(8mg/body weight) from 5th week to 8th week),Group2:36 rats fed on soya bean diet were divided into
three equal sub groups:Group2a:control soya bean diet (+ve), Group2b:rats fed on soya bean diet after
lead intoxicated (rats injected with lead acetate(8mg/body weight) from 1st week to 4th week), Group2c:
rats fed on soya bean diet before lead intoxicated((rats injected with lead acetate(8mg/body weight) from
5th week to 8th week). The results revealed that there was a significant increase in AST, ALT, Urea,
Creatinine and testosterone in rats fed on soya bean free diet before lead intoxicated, accompanied with
a significant decrease in Calcium, inorganic Phosphorus and Luteinizing hormone(LH) after 4th week
when compared with control (-ve) group . Also there was a significant increase in AST, ALT, Urea,
Creatinine, testosterone in rats fed on soya bean diet before lead intoxicated, accompanied with a
significant decrease in Calcium, inorganic Phosphorus and Luteinizing hormone (LH) when compared
with control (+ve) group. On the other hand, there was a significant increase in AST, ALT, Urea,
Creatinine and Testosterone in rats fed on soya bean free diet before lead intoxicated accompanied with
a significant decrease in inorganic Phosphorus, Calcium and Luteinizing hormone (LH), when compared
with control (-ve) group. Also there was a significant increase in AST, ALT, Urea, Creatinine and
Testosterone in rats fed on soya bean before lead intoxicated accompanied with significant decrease in
inorganic Phosphorus, Calcium and Luteinizing hormone (LH), when compared with control (+ve)
group. It concluded that the soya bean diet ameliorated bone and testis intoxicated with lead.
Keywords
lead intoxication; Rats; Soybean; gonad hormones; bone
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