The Effect Of PRP& Fat Grafting on Viability of Cartilage Grafts (An Experimental Study) | ||||
| The Egyptian Journal of Plastic and Reconstructive Surgery | ||||
| Articles in Press, Accepted Manuscript, Available Online from 13 September 2023 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejprs.2023.235634.1301 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
khaled mohammad Abdel Azeem   1; emad mohamed sayed2; wael sakr3; Ahmed Mohamed Ibrahem4; Osama M Ahmed5; mostafa fathy ibrahim 6
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| 1Plastic Surgery Department – Faculty of Medicine, Beni-Suef University- Beni-Suef, Egypt. | ||||
| 2Plastic and Reconstructive Surgery, Beni Suef University | ||||
| 3department of plastic surgery ,Beni Suef university, egypt. | ||||
| 4Faculty of Medicine | ||||
| 5Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt | ||||
| 6plastic surgery beni suef university | ||||
| Abstract | ||||
| Background: Cartilage tissue has limited capacity for regeneration mainly due to its avascular nature. As a result, cartilage deficiencies treatment has always been a difficult problem for surgeons. The objective of the study was to evaluate the safety and effectiveness of PRP and fat in cartilage grafting. Methods: This work was performed as a prospective manner on 20 young male New Zealand rabbits, each was an experimental unit for three subcutaneous pockets for cartilage grafts (plus PRP in first pocket and Microfat in second one while the third one kept without any additives). Weight, volume, and histopathology of inserted cartilage were evaluated after three months of insertion Results revealed decrease in weight and volume of all cartilage grafts. The findings of histopathology revealed that the tissues of cartilages showing maximum degeneration and losing of chondrocytes in intact cartilage without any additives followed by cartilage injected with PRP while the tissues of cartilages with fat showing minimum degeneration. The thickness of the cartilage grafts injected with fat was the largest followed by cartilage with PRP and cartilage without any additives respectively. Conclusion: PRP and Microfat are suitable biological wrapping materials for grafting of the cartilage that increases the viability of the grafts. The use of fat on cartilage graft gives the best findings on the volume and weight measurement as well as histopathological score followed by cartilage graft with PRP | ||||
| Keywords | ||||
| Structural cartilage; PRP; Microfat | ||||
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