Pushing the Boundaries of Diversity: Innovative Design and Synthesis of Hydrazone-Based Dynamic Combinatorial Libraries of Macrocycles | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 13, December 2023, Pages 1555-1561 PDF (1.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.228100.8399 | ||
| Author | ||
| Amal F. Seliem* | ||
| Department of Chemistry, College of Science and Arts, Najran University, P.O. Box 1988, Najran 11001, Saudi Arabia | ||
| Abstract | ||
| Dynamic combinatorial chemistry (DCC) has emerged as a versatile approach for generating and discovering materials with diverse applications. Utilizing acylhydrazone formation, we developed new dynamic combinatorial libraries (DCLs) of macrocycles and open-structured compounds with intriguing diversity. The DCL constituents were generated via condensation reactions using functionalized dihydrazides and aldehydes. Time-of-flight mass spectrometry (TOF-MS) was employed to analyze the library constituents, showcasing its great potential for characterizing DCLs generated by DCC. Our findings highlight the effectiveness of TOF-MS in verifying and validating complex macrocycles generated in solution, making it a valuable technique for discovering new materials through identification and validation of DCLs. | ||
| Keywords | ||
| Dynamic combinatorial chemistry; dihydrazide; dialdehyde; cyclocondensation; TOF-MS | ||
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