Role of Gamma Knife Radiosurgery in the Management of Diffuse Low Grade Astrocytoma
Gab Allah, G., Gad, O., Tag El-Din, E., Mahmoud, H., Twadrous, S., Nabeel, A., Abdel Karim, K. (2023). Role of Gamma Knife Radiosurgery in the Management of Diffuse Low Grade Astrocytoma. EKB Journal Management System, 7(3), 23-31. doi: 10.21608/jcbr.2023.204930.1302
Ghada Gab Allah; Omnia Abd El-Fattah Gad; Elsayed Ali Mohamed Tag El-Din; Hanan Shawky Mahmoud; Sameh Twadrous; Ahmed Nabeel; Khaled Abdel Karim. "Role of Gamma Knife Radiosurgery in the Management of Diffuse Low Grade Astrocytoma". EKB Journal Management System, 7, 3, 2023, 23-31. doi: 10.21608/jcbr.2023.204930.1302
Gab Allah, G., Gad, O., Tag El-Din, E., Mahmoud, H., Twadrous, S., Nabeel, A., Abdel Karim, K. (2023). 'Role of Gamma Knife Radiosurgery in the Management of Diffuse Low Grade Astrocytoma', EKB Journal Management System, 7(3), pp. 23-31. doi: 10.21608/jcbr.2023.204930.1302
Gab Allah, G., Gad, O., Tag El-Din, E., Mahmoud, H., Twadrous, S., Nabeel, A., Abdel Karim, K. Role of Gamma Knife Radiosurgery in the Management of Diffuse Low Grade Astrocytoma. EKB Journal Management System, 2023; 7(3): 23-31. doi: 10.21608/jcbr.2023.204930.1302

Role of Gamma Knife Radiosurgery in the Management of Diffuse Low Grade Astrocytoma

Egyptian Journal of Cancer and Biomedical Research
Volume 7, Issue 3, September 2023, Page 23-31  XML PDF (2.74 MB)
Document Type: Original Article
DOI: 10.21608/jcbr.2023.204930.1302
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Authors
Ghada Gab Allah email 1; Omnia Abd El-Fattah Gad2; Elsayed Ali Mohamed Tag El-Din3; Hanan Shawky Mahmoud3; Sameh Twadrous4; Ahmed Nabeel4; Khaled Abdel Karim5
1Department of Clinical Oncology & Nuclear Medicine, Faculty of Medicine, Tanta University
2Department of Clinical Oncology & Nuclear Medicine, Faculty of Medicine, Tanta University
3Department of Neurology, Faculty of Medicine, Tanta University, Tanta, Egypt
4Department of Neurosurgery, Ain Shams University, Cairo, Egypt
5Department of Clinical Oncology & Nuclear Medicine, Faculty of Medicine-Ain Shams University
Abstract
Introduction: low-grade astrocytomas represent a diverse group of primary brain tumors affecting young people. Gamma knife radiosurgery is a non-invasive therapeutic option for managing diffuse low-grade astrocytoma providing long-term tumor control and preventing debilitating treatment-related consequences, particularly for those in deep-seated structures or in critical locations.

Aim: evaluate the effectiveness, feasibility, and acute and subacute side effects of gamma knife radiosurgery in the management of patients with diffuse low-grade astrocytoma.

Methods: This non-randomized clinical trial was conducted on 68 patients with diffuse low-grade astrocytoma who were treated at a Gamma Knife Center, Nasser Institute, Cairo, Egypt.

Results: Tumor control after radiosurgery was achieved in 58 cases (15 of these tumors remained radiologically stable and 43 reduced in size) while 7 cases progressed (10.8% of cases). Gender, diagnosis either pathological or radiological, timing of GKRS, number of sessions and total tumor volume were found significantly affecting tumor response (p=0.038, p=0.001, p=0.010, p=0.008 and p=0.003 respectively). Acute toxicities included fatigue, alopecia, and headache and scalp erythema. Toxicities were minimal. No acute toxicities bigger than grade II of Common Terminology Criteria for Adverse Events v4.0 (CTCAE) were reported in treated patients. The progression free survival was 93.8% at 3 years, 90.8 % at 5 years an 89.2% at 8 years

Conclusions: Gamma Knife Radiosurgery offers patients with diffuse low-grade astrocytomas long lasting local tumour control with acceptable radiation toxicity, which improves patients' general health, PFS, functional performance and quality of life.
Keywords
Gamma Knife Radiosurgery; Diffuse Low Grade Astrocytoma; Radiosurgery
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