Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study
Bassyoni, O., Abdel Aal, E., khalil, A. (2023). Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study. EKB Journal Management System, 40(3), 745-758. doi: 10.21608/bmfj.2023.212530.1822
Omneya Youssef Bassyoni; Ebtehal Maher Abdel Aal; Ahmed khalil. "Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study". EKB Journal Management System, 40, 3, 2023, 745-758. doi: 10.21608/bmfj.2023.212530.1822
Bassyoni, O., Abdel Aal, E., khalil, A. (2023). 'Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study', EKB Journal Management System, 40(3), pp. 745-758. doi: 10.21608/bmfj.2023.212530.1822
Bassyoni, O., Abdel Aal, E., khalil, A. Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study. EKB Journal Management System, 2023; 40(3): 745-758. doi: 10.21608/bmfj.2023.212530.1822

Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study

Benha Medical Journal
Article 13, Volume 40, Issue 3, November and December 2023, Pages 745-758    PDF (1002.76 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.212530.1822
Authors
Omneya Youssef Bassyoni* 1; Ebtehal Maher Abdel Aal2; Ahmed khalil3
1department of pathology ,faculty of medicine ,Benha univeristy
2Pathology department, Benha faculty of medicine, Benha university, Kafr Shokre, Egypt
3Department of gynacology and obstatric ,faculty of medicine ,Benha univeristy
Abstract
BACKGROUND : Ovarian cancer is a lethal gynecological malignancy worldwide. The immune system plays a key role in preventing tumor development. Angiogenesis and immune evasion are vital for ovarian cancer progression and metastasis.
AIM: This work aimed to evaluate the expression of PD-L1, VEGF and CD8 +T cells in ovarian serous carcinomas and correlate them with clinicopathological variables.
MATERIAL AND METHODS: An Immunohistochemical study was performed on 50 cases of ovarian serous carcinomas.
RESULTS: PD-L1 & VEGF were over-expressed in higher grade, advanced stage , case with lymph node metastasis and distant metastasis .Higher CD8+ T cells in epithelium and stroma was related to advanced stage, only intraepithelial CD8+ T cells was directly correlated with tumor grade & lymph node metastasis positive correlation between PD-L1 & VEGF and Intraepithelial CD8+T cells was detected.
CONCLUSION: Neoplastic cells expressing PD-L1 and VEGF along with intraepithelial CD8+T cells might expect poor prognosis. An association between PD-L1 and VEGF could predict their role in immune evasion. Administration of immunotherapy (anti PD-L1) with antiangiogenic agents might increase antitumor activity. To enhance our knowledge about the immunological environment of epithelial ovarian tumors requires larger-scale studies.
Keywords
PD-L1; VEGF; CD8+T cells
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