Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study | ||
Benha Medical Journal | ||
Article 13, Volume 40, Issue 3, November and December 2023, Pages 745-758 PDF (1002.76 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/bmfj.2023.212530.1822 | ||
Authors | ||
Omneya Youssef Bassyoni* 1; Ebtehal Maher Abdel Aal2; Ahmed khalil3 | ||
1department of pathology ,faculty of medicine ,Benha univeristy | ||
2Pathology department, Benha faculty of medicine, Benha university, Kafr Shokre, Egypt | ||
3Department of gynacology and obstatric ,faculty of medicine ,Benha univeristy | ||
Abstract | ||
BACKGROUND : Ovarian cancer is a lethal gynecological malignancy worldwide. The immune system plays a key role in preventing tumor development. Angiogenesis and immune evasion are vital for ovarian cancer progression and metastasis. AIM: This work aimed to evaluate the expression of PD-L1, VEGF and CD8 +T cells in ovarian serous carcinomas and correlate them with clinicopathological variables. MATERIAL AND METHODS: An Immunohistochemical study was performed on 50 cases of ovarian serous carcinomas. RESULTS: PD-L1 & VEGF were over-expressed in higher grade, advanced stage , case with lymph node metastasis and distant metastasis .Higher CD8+ T cells in epithelium and stroma was related to advanced stage, only intraepithelial CD8+ T cells was directly correlated with tumor grade & lymph node metastasis positive correlation between PD-L1 & VEGF and Intraepithelial CD8+T cells was detected. CONCLUSION: Neoplastic cells expressing PD-L1 and VEGF along with intraepithelial CD8+T cells might expect poor prognosis. An association between PD-L1 and VEGF could predict their role in immune evasion. Administration of immunotherapy (anti PD-L1) with antiangiogenic agents might increase antitumor activity. To enhance our knowledge about the immunological environment of epithelial ovarian tumors requires larger-scale studies. | ||
Keywords | ||
PD-L1; VEGF; CD8+T cells | ||
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