Lymphocyte Subsets Expression of CD4 and CD8 in COVID-19 Infected Patients | ||
| Zagazig University Medical Journal | ||
| Article 17, Volume 30, Issue 4, July 2024, Pages 1173-1181 PDF (1.08 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2023.234175.2872 | ||
| Authors | ||
| Alaa Husseiny Meshref Esmail* 1; Ahmed Mohamed Baraka1; Tarek Hamdy Hassan2; Ahmed Mokhtar Ahmed1 | ||
| 1Clinical Pathology Department, Faculty of Medicine, Zagazig University | ||
| 2Chest Department, Faculty of Medicine, Zagazig University | ||
| Abstract | ||
| Background: Study of expression of lymphocyte subsets could help to understand the pathophysiology of COVID-19 infection, development of novel treatment protocols and reducing rate of mortality among COVID-19 infected patients. Objective: The aim of this work was to correlate expression of lymphocyte subsets with the inflammatory markers and clinical status of patients with COVID-19 infection. Patients and methods: This prospective study was performed at Zagazig University Isolation Hospitals and clinical pathology department, Zagazig, Egypt on 80 persons who were enrolled in this study; 40 COVID-19 patients with pneumonia made up group I, and the following individuals made up group II: 40 COVID-19 patients without pneumonia. Immunophenotyping of CD4 CD8 were measured by Flow Cytometry in both groups. Results: Patients had a considerable drop in CD4 CD8 levels with pneumonia than those without pneumonia Conclusion: Low levels of CD4 CD8 in COVID-19 patients are associated with a higher risk of pneumonia. | ||
| Keywords | ||
| Lymphocyte Subsets; CD4; CD8; IL6; COVID-19 | ||
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