Does Hypertension Contribute to Eliciting Gout Symptoms in Hyperuricemic Patients? | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 203, Volume 92, Issue 1, July 2023, Page 6824-6831 PDF (662.74 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2023.318798 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| Background and objective: Treatment of gout flares with uric acid-lowering medications is not optimal in hypertensive hyperuricemic patients and only sedates gout symptoms. The current study aimed to explore whether blood pressure control (BP) determines the symptomatic or asymptomatic status of hyperuricemic patients with elevated blood pressure. Patients and Methods: A cross-sectional study was conducted with 211 hypertensive hyperuricemic participants obtained from the King Saud Medical City (KSMC). All patients were categorized into three blood pressure groups: controlled, uncontrolled, and untreated hypertension groups. Based on uric acid (UA) levels, the participants were divided into three UA tertiles: T1, <157 µmol/L, T2:157-360 µmol/L and T3:>360 µmol/L. Descriptive statistics of the study variables and multivariate regression analysis were utilized to determine the association between gout joint flares and blood pressure after adjustment of the risk factors. Results: The findings revealed an increased prevalence of gout symptoms across the three BP groups. Moreover, this association was significant even after adjustment of the age, gender, BMI, and smoking. Also, there was a significant gout-symptoms difference when comparing the corresponding UA tertiles in each blood pressure group. Moreover, a significant positive association existed between blood pressure and the frequency and number of gouty attacks. The more controlled blood pressure, the less frequent and short-duration attacks. Conclusion: Hypertension was strongly suggested as a major risk factor in eliciting gout symptoms in hyperuricemic patients, whatever is the level of serum uric acid. | ||||
| Keywords | ||||
| Blood pressure; Gout; Symptomatic hyperuricemia; Serum uric acid level | ||||
|
Statistics Article View: 238 PDF Download: 357 |
||||
