Gero-protective Impact of Astaxanthin on Experimental Model of Brain Aging: Biochemical and Molecular Study | ||
| Egyptian Journal of Chemistry | ||
| Volume 67, Issue 3, March 2024, Pages 297-307 PDF (437.41 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.232470.8520 | ||
| Authors | ||
| Hanadi M. Baeissa1; Aminah A. Barqawi2; Manal A. Tashkandi1; Leena S. Alqahtani1; Reem Al-azragi1; Neveen A. Salem3; Rasha H. Hussein* 1, 4 | ||
| 1Department of Biochemistry, College of Science ,University of Jeddah ,Jeddah, Saudi Arabia | ||
| 2Department of Chemistry , College of Science ,Umm Al Qura University, Makkah Al-Mukarramah, Saudi Arabia | ||
| 3Narcotics, Ergogenics, and Poisons Department , National Research Centre (NRC), Cairo, Egypt | ||
| 4Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education Ain Shams University , Cairo, Egypt. | ||
| Abstract | ||
| Brain activity and multiple organ functions declined with aging. Although the complexity of brain aging process, releasing free radicals and inflammation were strongly linked to the disorder. Astaxanthin is a dietary carotenoid which exerts antioxidant and anti-inflammatory activities. We intended to estimate the protecting impact of Astaxanthin on aging caused by D-galactose. Forty male Wister rats were separated into 4 groups as follow: G1: (control) group:G2: (D-Gal) rats received D-Gal (300mg/kg,ip) ;G3 (D-Gal+Met) 4 h after D-Gal administration, rats received metformin (300 mg/kg, orally) , as reference drug group;G4 : (D-Gal+Asta) group: 4h after D-Gal treatment, rats received Astaxanthin (25 mg/kg , orally). Results showed that administering D-Gal caused brain aging manifested by significant (p<0.05) disturbance of antioxidant defense system, inflammatory biomarkers. Moreover, results of gene expression and histological assessment ensured biochemical findings. Astaxanthin supplementation promoted a remarkable significant (p<0.05) normalization in all parameters by triggering different brain mechanisms. In conclusion these results suggested that Astaxanthin modulates D-Gal induced brain-abnormalities associated with aging. | ||
| Keywords | ||
| Astaxanthin; Brain Aging; D-Galactose; Gero-protective | ||
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