Eco-friendly and Regiospecific synthesis of Novel (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide Derivatives | ||
| Sohag Journal of Sciences | ||
| Volume 9, Issue 1, March 2024, Pages 64-68 PDF (326.62 K) | ||
| Document Type: Regular Articles | ||
| DOI: 10.21608/sjsci.2023.232963.1120 | ||
| Authors | ||
| Amer A. Amer* 1; Doaa H. Ahmed1; Amr H. Moustafa1, 2 | ||
| 1Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt. | ||
| 2Faculty of Science, King Salman International University, Ras Sudr, Sinai 46612, Egypt. | ||
| Abstract | ||
| The Ultrasonic (US) technique is used in the present work as an eco-friendly method for the synthesis of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide derivatives. A simple and efficient method has been described for the alkylation of (5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide (1). Besides the IR and NMR spectra, the regioselectivity of the N-alkylation is chemically achieved. Furthermore, fusion of sodium salt of 1 with ethyl bromide in DMF as solvent using ultrasound irradiation as a source of power afforded (1,3-diethyl-5-oxo-4,4-diphenylimidazolidin-2-ylidene)cyanamide (9). | ||
| Keywords | ||
| Ultrasonic technique; Eco-friendly; Cyanoguanidinophenytoin; Regioselectivity; Alkylation | ||
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