One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines | ||
| Sohag Journal of Sciences | ||
| Volume 9, Issue 1, March 2024, Pages 76-80 PDF (330.46 K) | ||
| Document Type: Regular Articles | ||
| DOI: 10.21608/sjsci.2023.227734.1111 | ||
| Authors | ||
| Hayam H. Mohammed; Eman A. Ahmed; Bahgat R. M. Hussein* ; Omran A. Abdellah | ||
| Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt | ||
| Abstract | ||
| In this work, we synthesized a novel arylidene malononitrile 3 via the treatment of o-alkyl vanillin derivative 1 with malononitrile 2 in the presence of triethylamine (TEA) as a catalyst. The arylidene malononitrile 3 was subjected to react under one-pot multicomponent reaction (MCR) condition with respective methylarylketones 4a-f and sodium ethoxide 5 in ethanol to afford a new series of 2-(4-(6-aryl-3-cyano-2-ethoxypyridin-4-yl)-2-methoxyphenoxy)-N-phenylacetamides 6a-f. The structure of the new products was assured via spectral and elemental analysis. The reaction mechanism was suggested. | ||
| Keywords | ||
| O-alkyl vanillin; pyridine derivatives; arylidene; N-phenylacetamide; multicomponent reaction | ||
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