One-pot Multicomponent Synthesis of Novel Polyfunctionalized Pyridines | ||||
| Sohag Journal of Sciences | ||||
| Volume 9, Issue 1, March 2024, Page 76-80 PDF (330.46 K) | ||||
| Document Type: Regular Articles | ||||
| DOI: 10.21608/sjsci.2023.227734.1111 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hayam H. Mohammed; Eman A. Ahmed; Bahgat R. M. Hussein   ; Omran A. Abdellah
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| Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt | ||||
| Abstract | ||||
| In this work, we synthesized a novel arylidene malononitrile 3 via the treatment of o-alkyl vanillin derivative 1 with malononitrile 2 in the presence of triethylamine (TEA) as a catalyst. The arylidene malononitrile 3 was subjected to react under one-pot multicomponent reaction (MCR) condition with respective methylarylketones 4a-f and sodium ethoxide 5 in ethanol to afford a new series of 2-(4-(6-aryl-3-cyano-2-ethoxypyridin-4-yl)-2-methoxyphenoxy)-N-phenylacetamides 6a-f. The structure of the new products was assured via spectral and elemental analysis. The reaction mechanism was suggested. | ||||
| Keywords | ||||
| O-alkyl vanillin; pyridine derivatives; arylidene; N-phenylacetamide; multicomponent reaction | ||||
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