The Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio can be Considered as Valuable Markers of Disease Activity in Ankylosing Spondylitis
Hassan, I., Abd-EL Ghany, F., mortada, M., Alqurashi, L., Elgawish, M. (2024). The Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio can be Considered as Valuable Markers of Disease Activity in Ankylosing Spondylitis. EKB Journal Management System, 30(1.7), 3761-3771. doi: 10.21608/zumj.2023.238771.2920
Inas Farid Hassan; Fadya Abd-EL Ghany; Mohamed atia mortada; Lobna A. Alqurashi; Mohammad Hassan Elgawish. "The Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio can be Considered as Valuable Markers of Disease Activity in Ankylosing Spondylitis". EKB Journal Management System, 30, 1.7, 2024, 3761-3771. doi: 10.21608/zumj.2023.238771.2920
Hassan, I., Abd-EL Ghany, F., mortada, M., Alqurashi, L., Elgawish, M. (2024). 'The Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio can be Considered as Valuable Markers of Disease Activity in Ankylosing Spondylitis', EKB Journal Management System, 30(1.7), pp. 3761-3771. doi: 10.21608/zumj.2023.238771.2920
Hassan, I., Abd-EL Ghany, F., mortada, M., Alqurashi, L., Elgawish, M. The Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio can be Considered as Valuable Markers of Disease Activity in Ankylosing Spondylitis. EKB Journal Management System, 2024; 30(1.7): 3761-3771. doi: 10.21608/zumj.2023.238771.2920

The Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio can be Considered as Valuable Markers of Disease Activity in Ankylosing Spondylitis

Zagazig University Medical Journal
Article 8, Volume 30, Issue 1.7, October 2024, Page 3761-3771  XML PDF (1019.66 K)
Document Type: Original Article
DOI: 10.21608/zumj.2023.238771.2920
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Authors
Inas Farid Hassan email 1; Fadya Abd-EL Ghany2; Mohamed atia mortada3; Lobna A. Alqurashi4; Mohammad Hassan Elgawish2
1Rheumatology and Rehabilitation Department Qenayat Central Hospital, Zagazig
2Rheumatology & Rehabilitation Faculty of Medicine - Zagazig University
3Rheumatology & Rehabilitation department faculty of medicine, Zagazig university
4Microbiology Department, Faculty of Medicine, Zagazig University
Abstract
Abstract

Background: There is role of the platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) as laboratory biomarkers that detect the presence and activity of different diseases. Measuring the PLR and NLR levels as possible indicators of activity status among ankylosing spondylitis (AS) patients was the main goal of the current study. Methods: This study included 86 subjects divided into 43 AS patients and 43 apparently healthy volunteers serving as controls. For assessment of disease activity among AS patients we used the Bath AS Disease Activity Index (BASDAI), by which the studied AS patients were split to the following groups based on their level of activity; one group considered as inactive group (BASDAⅠ < 4) and the second group considered as active group (BASDAⅠ ≥ 4), laboratory data were collected from studied participants as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), complete blood count including white blood cell count, neutrophil, lymphocyte and platelet counts. Results: PLR and NLR ratios were not significantly differ between AS patients and healthy control group as (P > 0.05), however both PLR and NLR ratios were significantly differ between inactive (BASDAⅠ < 4) and active (BASDAⅠ ≥ 4) studied AS patients (P<0.05). BASDAI score was significantly correlated with PLR, NLR, CRP and ESR among AS patients. Conclusion: PLR and NLR ratios are both useful indicators for determining and tracking disease activity among AS patients.
Keywords
Keywords: Activity; NLR; PLR; Ankylosing Spondylitis
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