EFFICACY AND RESIDUES OF OXOLINIC ACID IN OREOCHROMIS NILOTICUS FISH INFECTED WITH ENTERIC RED MOUYH DISEASE (ERM) | ||
| Egyptian Journal of Agricultural Research | ||
| Article 29, Volume 78, Issue 1, March 2000, Pages 399-409 PDF (2.62 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejar.2000.321705 | ||
| Authors | ||
| MONA M. HUSIEN; ABAS A. YOUNIS | ||
| Animal Health Research Institute, Agricultural Research Centre, Dokki, Giza, Egypt | ||
| Abstract | ||
| Efficacy and residues of oxolinic acid in tissues of experimentally inoculated Oreochromis niloticus fish with Yersinia ruckeri (Y.rucken) have been investigated. Results of the in-vitro stuy revealed that the used bacterial isolate was sensitive to oxolinic acid. The in-vivo treatment test indicated a high effectiveness of oxolinic acid when given orally in the diet at a dose rate of 10 mg/kg body weight for ten successive days. The haematological inestigations in experimentally infected fish proved a decrease in some blood parameters namely, RBCs, WBCs count, Hb content and P.C.V. volume pre-treatment with oxolinic acid, but they returned to their normal values post-treatment. The residual analysis indicated the presence of oxolinic acid residues in the muscles, kidney and liver of treated fish up to 15, 20 and 25 days post-treatment, resppectively. | ||
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