Antitumor efficacy of the Egyptian scorpion Leiurus quinquestriatus whole body extract in EAC-bearing mice
Salama, W., El-Newahy, A., Sakr, S., El-desoky, N. (2023). Antitumor efficacy of the Egyptian scorpion Leiurus quinquestriatus whole body extract in EAC-bearing mice. EKB Journal Management System, 1(2), 27-34. doi: 10.21608/bbj.2023.321883
Wesam Salama; Abdelwahab El-Newahy; Soha Sakr; Nabila El-desoky. "Antitumor efficacy of the Egyptian scorpion Leiurus quinquestriatus whole body extract in EAC-bearing mice". EKB Journal Management System, 1, 2, 2023, 27-34. doi: 10.21608/bbj.2023.321883
Salama, W., El-Newahy, A., Sakr, S., El-desoky, N. (2023). 'Antitumor efficacy of the Egyptian scorpion Leiurus quinquestriatus whole body extract in EAC-bearing mice', EKB Journal Management System, 1(2), pp. 27-34. doi: 10.21608/bbj.2023.321883
Salama, W., El-Newahy, A., Sakr, S., El-desoky, N. Antitumor efficacy of the Egyptian scorpion Leiurus quinquestriatus whole body extract in EAC-bearing mice. EKB Journal Management System, 2023; 1(2): 27-34. doi: 10.21608/bbj.2023.321883

Antitumor efficacy of the Egyptian scorpion Leiurus quinquestriatus whole body extract in EAC-bearing mice

Biological and Biomedical Journal
Volume 1, Issue 2 - Serial Number 1, July 2023, Page 27-34  XML PDF (557.07 K)
Document Type: Research Articles
DOI: 10.21608/bbj.2023.321883
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Authors
Wesam Salama email orcid 1; Abdelwahab El-Newahy2; Soha Sakr3; Nabila El-desoky2
1Zoology Department, Faculty of Science, Tanta University, Egypt. Zoology Department, Faculty of Science, Tanta University
2Department of Zoology, Faculty of Science, Tanta University, Tanta 31527, Egypt
3Home Economics Department, Faculty of Specific Education, Tanta University
Abstract
Cancer chemotherapy is an effective setting for treatments; however, it own severe side effects on vital organs. This study was conducted to evaluate the efficacy of Leiurus quinquestratus scorpion whole-body extract (LQWBE) as anticancer agent. Furthermore, the hepatic protective effect of LQWBE was evaluated. Forty female CD-1 mice were divided into four groups (n = 10). All groups were inoculated with 1x106 EAC-cells/mouse. After 24 h of inoculation, group 1 (Gp1) left as EAC-bearing mice alone. Gp2 was injected with LQWBE (50 mg/Kg). Gp3 was injected with Cis (2 mg/Kg), while, Gp4 was injected with Cis/LQWBE as in Gp3 and Gp4. All injections were intraperitoneally (i.p), daily for 7 days. At day 14, the percentages of body weight changes (% b.wt), and tumor profile were determined. Hematological, biochemical, and histopathological investigations were assessed. The results showed that the effect of LQWBE had a moderate antitumor effect, however, provides a protective effect on hepatic tissues in EAC-bearing mice
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