Co-treatment with saponin and metformin improves the biochemical status of type 2 diabetes mellitus rats | ||||
| Biological and Biomedical Journal | ||||
| Volume 1, Issue 2 - Serial Number 1, July 2023, Page 58-65 PDF (313.6 K) | ||||
| Document Type: Research Articles | ||||
| DOI: 10.21608/bbj.2023.321886 | ||||
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| Authors | ||||
Karim S. EL-Said  ; Yomna A. Elbarbary; Amro E. Mohamed
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| Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Egypt | ||||
| Abstract | ||||
| Saponins (Sap) are effective bioactive compounds for ameliorating various diseases complications. This study addressed the effects of co-treatment with Sap and metformin (Met) on the biochemical status of type 2 diabetes mellitus (T2-DM) rats. Forty male Sprague-Dawley rats were divided into 5 groups (n = 8) as follows: group 1 (Gp1) was the negative control group. Gp2 was fed on a high fat diet (HFD) for 8 weeks (wks) and received a single intraperitoneal (i.p) injection of 30 mg/kg streptozotocin (STZ) after 8 wks to induce T2-DM. Gp3 was treated as Gp2, after 8 wks rats received 250 mg/kg Met by oral gavage daily for 4 weeks. Gp4 was treated as Gp2, and after 8 wks rats received 300 mg/kg Sap by oral gavage daily for 4 weeks. Gp5 was treated as Gp2, after the 8 wks rats received it, and then co-treated with Met as in Gp3 and Sap as in Gp4. The percentage of body weight (% b.wt) changes, hematological, and biochemical parameters were determined. The results showed that co-treatment with Met and Sap led to significant improvement in the % b.wt of T2-DM rats. Co-treatment of T2-DM rats with Met and Sap led to synergistic effects in the reduction of serum glucose levels and an increase in the C-peptide levels. Co-treatment of T2-DM rats with Met and Sap led to significant improvements in the hepato-renal functions and antioxidant status. Sap could play an important role in regulating T2-DM and can be developed as a promising natural material for diabetes management. | ||||
| Keywords | ||||
| Type 2 diabetes mellitus; Saponin; Metformin; Antidiabetic; Biochemical status | ||||
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