Saccharomyces cerevisiae - Fermented Garlic Attenuates Gamma-irradiation Induced Brain and Liver Toxicity Via Regulation of the NF-κB and STAT3 Signaling Pathway
El-Sonbaty, S., Fahmy, H., Ismail, A. (2023). Saccharomyces cerevisiae - Fermented Garlic Attenuates Gamma-irradiation Induced Brain and Liver Toxicity Via Regulation of the NF-κB and STAT3 Signaling Pathway. EKB Journal Management System, 36(1), 33-45. doi: 10.21608/ejrsa.2023.236135.1161
Sawsan M. El-Sonbaty; Hanan A. Fahmy; Amel F.M. Ismail. "Saccharomyces cerevisiae - Fermented Garlic Attenuates Gamma-irradiation Induced Brain and Liver Toxicity Via Regulation of the NF-κB and STAT3 Signaling Pathway". EKB Journal Management System, 36, 1, 2023, 33-45. doi: 10.21608/ejrsa.2023.236135.1161
El-Sonbaty, S., Fahmy, H., Ismail, A. (2023). 'Saccharomyces cerevisiae - Fermented Garlic Attenuates Gamma-irradiation Induced Brain and Liver Toxicity Via Regulation of the NF-κB and STAT3 Signaling Pathway', EKB Journal Management System, 36(1), pp. 33-45. doi: 10.21608/ejrsa.2023.236135.1161
El-Sonbaty, S., Fahmy, H., Ismail, A. Saccharomyces cerevisiae - Fermented Garlic Attenuates Gamma-irradiation Induced Brain and Liver Toxicity Via Regulation of the NF-κB and STAT3 Signaling Pathway. EKB Journal Management System, 2023; 36(1): 33-45. doi: 10.21608/ejrsa.2023.236135.1161

Saccharomyces cerevisiae - Fermented Garlic Attenuates Gamma-irradiation Induced Brain and Liver Toxicity Via Regulation of the NF-κB and STAT3 Signaling Pathway

Egyptian Journal of Radiation Sciences and Applications
Volume 36, Issue 1, 2023, Pages 33-45    PDF (6.17 M)
Document Type: Original Article
DOI: 10.21608/ejrsa.2023.236135.1161
Authors
Sawsan M. El-Sonbaty1; Hanan A. Fahmy2; Amel F.M. Ismail* 2
1Radiation Microbiology Department, National Center for Radiation Research and Technology (NCRRT). Egyptian Atomic Energy Authority, Cairo, Egypt
2Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT). Egyptian Atomic Energy Authority, Cairo, Egypt
Abstract
The present study was designed to evaluate the radio-protective effects of Saccharomyces cerevisiae-fermented garlic extract (FGE) on γ-irradiation-induced acute toxicity in rats' brain and liver. The rats were divided into four groups, Group I (C; control group) and III (R: irradiated rats) rats administered orally with 1 ml of water. Group II (FGE) and IV (FGE+R): rats administered orally with 1 ml of fermented garlic extract (FGE).  Then after 21 days of treatment, rats of groups III, and IV were exposed to a single shot of whole-body gamma irradiation (6 Gy).  The results showed that γ-irradiation significantly increased the activity of the hepatic enzymes; ALT, AST, ALP, GGT, and the levels of Total-cholesterol and Triglycerides in the serum.  In addition, the activity of SOD, and GSH-Px were significantly decreased, with alteration in the trace elements levels were observed in the brain and liver cytosolic fractions.  Moreover, the levels of MDA, and the pro-inflammatory markers; TNF-α, IL-1β, IL-6 and Caspase-3 activity were significantly elevated, GSH content was significantly decreased (p<0.001), the gene expression ratios of NF-κB and STAT3 showed significant up-regulation (p<0.001) as well as DNA fragmentation were also observed in brain and liver tissues.  FGE pre-treatment has significantly ameliorated the changes in all these studied parameters.  These findings could suggest that the bioactivities of FGE showed neuro-hepato-protective effects on acute toxicity of gamma irradiation by improving the antioxidant system, anti-inflammatory and anti-apoptotic activities associated with regulation of the NF-κB and STAT3 signaling pathway in rats’ brain and liver.
Keywords
Antioxidant status; Fermentation; Radioprotection; Trace elements; Yeast
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