Assessment of Stefin-A Gene Expression in Breast Cancer Women | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 1.2, January and February 2024, Page 449-457 PDF (928.31 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2023.245731.2992 | ||||
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| Authors | ||||
Eman Salah Nagdy   1; Basma A Ibrahim 1; Alaa mohamed Ibrahim 2
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| 1Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 2General Surgery Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Abstract Background: Breast cancer (BC) is a very malignant tumor that is responsible for most cancer-related fatalities in women all over the world. The objective of the present study was to evaluate the potential of circulating Stefin-A and cancer antigen 15-3 (CA15-3) as tumor biomarkers in localized BC patients and those with metastatic BC. Method: The study was a case-control study, that included 108 Egyptian females who were classified into three groups: healthy control, localized BC, and metastatic BC groups. The Stefin-A relative expression level was measured in the blood utilizing quantitative real-time polymerase chain reaction (qRT-PCR) while the serum level of CA15-3 was measured by ELISA. Results: Stefin-A expression was statistically significantly higher among BC patients than metastatic BC patients than the healthy group (p-value: 0.001). Among localized BC patients, there was a statistically positive correlation between Stefin-A and CA15-3 (r=0.58 and p<0.001). While, among BC patients with metastasis, there was a statistically significant negative correlation between them (r=-0.36 and p=0.03). Conclusion: According to our results, we indicate that Stefin-A is negatively associated with the progression, invasiveness, and lymphatic metastasis of BC, and strongly, Stefin-A may be useful in molecular diagnosis and gene therapy for BC. | ||||
| Keywords | ||||
| Keywords: Breast Cancer; Metastasis; Stefin-A; CA15-3; Gene Expression | ||||
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