Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center: Cohert Study
Mahmoud, M., Ali, M., Khattab, H., Abdalrahman, A., Mohamed, A., Abdalaziz, A. (2023). Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center: Cohert Study. EKB Journal Management System, 16(4), 281-289. doi: 10.21608/asjs.2023.325718
Mahmoud Abdelbaky Mahmoud; Mohamed Ebrahim Mohamed Ali; Hany Mahmoud Khattab; Ali Alsaaed Abdalrahman; Ahmed Taher Mohamed; Abdalrahman Mohamed Abdalaziz. "Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center: Cohert Study". EKB Journal Management System, 16, 4, 2023, 281-289. doi: 10.21608/asjs.2023.325718
Mahmoud, M., Ali, M., Khattab, H., Abdalrahman, A., Mohamed, A., Abdalaziz, A. (2023). 'Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center: Cohert Study', EKB Journal Management System, 16(4), pp. 281-289. doi: 10.21608/asjs.2023.325718
Mahmoud, M., Ali, M., Khattab, H., Abdalrahman, A., Mohamed, A., Abdalaziz, A. Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center: Cohert Study. EKB Journal Management System, 2023; 16(4): 281-289. doi: 10.21608/asjs.2023.325718

Comparative Study between Results of Neo Adjuvant Chemotherapy and Upfront Surgery in Breast Cancer in Aswan Oncology Center: Cohert Study

Ain Shams Journal of Surgery
Volume 16, Issue 4, October 2023, Page 281-289  XML PDF (377.44 K)
Document Type: Original Article
DOI: 10.21608/asjs.2023.325718
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Authors
Mahmoud Abdelbaky Mahmoud* 1; Mohamed Ebrahim Mohamed Ali1; Hany Mahmoud Khattab2; Ali Alsaaed Abdalrahman3; Ahmed Taher Mohamed4; Abdalrahman Mohamed Abdalaziz1
1Department of General Surgery, Faculty of Medicine, Ain Shams University
2Department of Pathology, Faculty of Medicine, Cairo University
3Department of Radiology, National Hepatology and Tropical Institute, Aswan Oncology Center
4Consultant Medical Oncology, Aswan Oncology Center
Abstract
Background: Breast cancer affects millions of people globally each year, making it a major health concern. The
management of breast cancer has undergone a significant transformation with the introduction of neoadjuvant
chemotherapy (NACT).
Aim and objectives: Neoadjuvant chemotherapy and upfront surgery for breast cancer were compared in terms
of clinicopathological characteristics, surgical techniques, and outcome metrics with the goal of comparing the
outcomes in term of local recurrence rates and metastasis in 2 groups.
Subjects and methods: This is a comparative research, which included (40) women who had been diagnosed
with breast cancer and were split into two groups: In group A: 20 patients underwent upfront surgery, Group B: 20
patients recieved neo adjuvant chemotherapy over a year.
Result: The two study groups differed statistically significantly in terms of local recurrence and metastatic work up.
Conclusion: Neoadjuvant chemotherapy significantly increases the risk of metastasis compared to upfront surgery
while having a marginally positive effect on pathological complete response (PCR) in patients with breast cancer. We
discovered that upfront surgery is preferable in the treatment of early breast cancer, but neoadjuvant chemotherapy
is preferable in the treatment of late breast cancer.
Keywords
Breast Cancer; Neoadjuvant Chemotherapy; Surgery; Outcome
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