Utilization of Multi Component Reactions in the Synthesis of 1,6-Naphthyridine Derivatives with Expected Biological Activity | ||
| Egyptian Journal of Chemistry | ||
| Volume 67, Issue 6, June 2024, Pages 151-156 PDF (599.05 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2023.239412.8682 | ||
| Authors | ||
| Abdullah Y. Abdullah Alzahrani1; Amira Atef* 2; Wassila Derafa3; Nesrin M. Morsy4 | ||
| 1Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail Assir, Saudi Arabia | ||
| 2Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt. | ||
| 3bChemistry Department, College of Science, Jouf University, Sakaka 2014, Saudi Arabia | ||
| 4Organometallic and Organometalloid Chemistry Department,National Research Centre, Cairo,12622, Dokki, Egypt. | ||
| Abstract | ||
| We have achieved the diastereo selective synthesis of pyrano and furano naphthyridine derivatives through the utilization of Camphor sulfonic acid (CSA) as a catalyst in an ABB' type multi component coupling reaction involving 4-aminopyridine and cyclic enol ethers to form of pyrano and furano naphthyridine in high yields, primarily exhibiting cis diastereo selectivity. Notably, the addition of water as a reagent causes a shift in diastereoselectivity towards the trans isomer. Synthesized compounds were evaluated in vitro for their antimicrobial activities and molecular docking studies were performed. | ||
| Keywords | ||
| Pyrano naphthyridine; furano naphthyridine; Camphor sulfonic acid; Cycloaddition; Organocatalyst | ||
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