HISTOLOGICAL EVALUATION OF ANGELICA SINENSIS IN MANAGEMENT OF CLASS II FURCATION DEFECT (AN EXPERIMENTAL STUDY) | ||
| Alexandria Dental Journal | ||
| Article 9, Volume 48, Issue 3, December 2023, Pages 62-69 PDF (483.83 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/adjalexu.2023.176994.1328 | ||
| Authors | ||
| Dina W. Eldeeb* 1; Ahmed Mohamed Hommos2; Maha Ramzy Talaab3; Samia Soliman4 | ||
| 1periodontology, faculty of dentistry, Alexandria university , Egypt | ||
| 2Professor, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University | ||
| 3Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology Department , Faculty of dentistry , Alexandria university | ||
| 4Professor, Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt | ||
| Abstract | ||
| Introduction: proper management of furcation involvements has always been a demanding issue in periodontal therapy. Herbal medicine is nowadays proposed to provide novel alternative approaches for restoring defective bone. A Chinese herb known as Angelica sinensis (As) has various pharmacological effects as it promotes proliferation and differentiation of osteoblasts Objectives: The aim of this study was to evaluate the effectiveness of Angelica sinensis in conjunction with β-tricalcium phosphate in the management of class II furcation defects in dogs Materials and Methods: This randomized study was carried on 6 clinically healthy mongrel dogs. 24 grade II critical-sized furcation defects were surgically created in the mandibular third and fourth premolars. 12 defects were filled with Beta-tricalcium phosphate (β-TCP) bone graft only (control group). While in the other 12 defects β-TCP was mixed with Angelica sinensis powder (experimental group). The defects were covered by collagen membrane, The dogs were sacrificed at 4 and 8 weeks postoperative. Results: The histological analysis has revealed better regenerative features regarding alveolar bone, periodontal ligament and cementum in the experimental groups when compared to control groups. Conclusions: Angelica sinensis herb could enhance the periodontal regenerative potential of β-TCP bone graft. | ||
| Keywords | ||
| Angelica sinensis; bone graft; furcation; β-TCP | ||
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