COMPARISON EFFECT OF DIFFERENT COMBINATIONS OF METFORMIN, ATORVASTATIN, CAPTOPRIL AND ASPIRIN ON OXIDATIVE STRESS MARKERS OF GASTRIC AND LIVER TISSUES OF DIABETIC RATS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Volume 46, Issue 2, December 2023, Page 1397-1406 PDF (1.22 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2023.327570 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Saeed Niazmand1; Reza Mohebbati2; Masoomeh Mirzaee1; Mahdiyeh Hedayati-Moghadam 3; Morteza Ahmad Abadi4; Maryam Paseban  5
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| 1Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||||
| 2Department of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran | ||||
| 3Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran | ||||
| 4Department of Environmental Health Engineering, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran | ||||
| 5Innovative Medical Research Center and Department of physiology, Faculty of Medicine, Mashhad medical science Islamic Azad University, Mashhad, Iran Student research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran | ||||
| Abstract | ||||
| Some recent studies have been suggested high - dose aspirin consumption in diabetic patient because of its modifying effect on metabolism of glucose and lipid. In other side many researches showed aspirin induced gastrointestinal damage. Investigation of the effect of high-dose aspirin consumption in combinations with metformin, captopril and atorvastatin on oxidative stress markers in the stomach and liver tissues of diabetic rats. Rats divided into eleven groups: control (Cont), diabetic (D), and 9 treated groups with various combination of metformin (M), atorvastatin (AT), captopril (C), and aspirin (ASA). Animals were treated orally by M, C, AT and ASA daily for 6 weeks. Finally, oxidative markers were evaluated in stomach and liver tissues. The Malondialdehyde (MDA) level significantly boosted while total thiol content remarkably decreased in the diabetic group than the control. Administration of the different combinations of C, M, AT and ASA could significantly attenuate above parameters. Combination of the metformin, aspirin, atorvastatin and captopril has more marked effects on oxidative stress reduction in the stomach and liver tissues of diabetic rats and could ameliorated probably oxidative stress induced by aspirin. | ||||
| Keywords | ||||
| Diabetes; Stomach; Liver; Aspirin; Drugs combination | ||||
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