Assessment of Serum Protein Carbonyls and Glycemic Biomarkers in Patients with Type 2 Diabetic Proliferative Retinopathy | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Volume 15, Issue 2, December 2023, Page 805-811 PDF (592.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2023.329310 | ||||
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| Authors | ||||
| Zaid Najah Neamah1; Omar F. bdul Rasheed1; Alyaa Aboode Kareem2 | ||||
| 1Department of Chemistry and Biochemistry University of AL-Nahrain. | ||||
| 2Ophthalmology Department medical faculty, Al Kufa University. | ||||
| Abstract | ||||
| Purpose: A case-control study was conducted to evaluate the role of protencarponyls and glycemic biomarkers in type two diabetic patients with proliferative diabetic retinopathy (PDR).Materials and Methods: a case-control study includes a comparison between 3 groups, (40 healthy persons ) as a control compared with (40 type-2 diabetic patients without proliferative retinopathy) and (40 diabetic patients with proliferative retinopathy) serum PC were determined with ELISA while glycemic biomarkers FBS, HbA1c was determined by spectrophotometry method ( autoanlyser technique). Result: PC serum level and FBS, HbA1c statistically significantly increased among the study groups, the highest level in PDR patients when compared with control groups and T2M Patients without RP. Conclusion: Protein carbonyls are increased significantly in both T2DM without PDR and PDR patients compared with healthy people ( control ).FBS and HbA1c decreased significantly in both T2DM without PDR and PDR patients compared with healthy people ( control ). | ||||
| Keywords | ||||
| PDR: Proliferative Diabetic RetinopathyPCs: protein carbonyls; T2DM: Type 2 Diabetes Mellitus; FBS: Fasting Blood Sugar; HbA1C: Glycated Hemoglobin | ||||
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